Long-term risk assessment of vaginal intraepithelial neoplasia in patients with cervical neoplasia
Official title: Longitudinal Study of Human Papillomavirus (HPV) Genotyping and Pap Smear in Patients With Antecedent Cervical Intraepithelial Neoplasia (CIN) and Association With Vaginal Intraepithelial Neoplasia (VAIN)
Run by Chang Gung Memorial Hospital · NCT05931354 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is trying to see how different types of HPV affect the long-term risk of developing vaginal changes in women who have had cervical issues.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years and up |
| Sex | Women only |
| Enrollment | 600 (estimated) |
| Sponsor | Chang Gung Memorial Hospital Academic / other |
| Locations | 1 site (Taoyuan City) |
| Trial ID | NCT05931354 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged 20 years and older with a previous history of CIN.
✕Probably not a fit
Patients without a history of cervical intraepithelial neoplasia or those under 20 years old may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to construct a longitudinal risk model for vaginal intraepithelial neoplasia (VAIN) based on the distribution of human papillomavirus (HPV) types in patients with a history of cervical intraepithelial neoplasia (CIN2+). It will include three arms to gather follow-up data from a previous cohort while also prospectively recruiting new subjects to enhance the sample size. The study addresses the lack of long-term outcome data for patients with antecedent CIN and aims to better understand the relationship between HPV and VAIN progression.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the risk factors for VAIN, potentially leading to improved screening and management strategies for affected patients.
How similar studies have gone: While there have been limited studies on VAIN, this approach is novel in constructing a longitudinal risk model specifically for this condition.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age \>= 20 years 2. Those with a previous history of CIN+
Where it's running
-
Chang Gung Medical Foundation
Taoyuan City, Taiwan Recruiting
Study contacts
- Study coordinator: Lan-Yan Yang, PhD
- Email: lyyang0111@gmail.com
- Phone: 88633281200
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.