Long-Term Look at Long COVID after COVID-19

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows people with a past SARS-CoV-2 infection to measure how often Long COVID symptoms occur, how severe they are, and how they persist. Participants provide health information through surveys and give saliva samples for analysis of proteins, metabolites, microbes, and immune markers. Machine learning will combine demographic, clinical, symptom, and saliva data to identify patterns that predict persistent symptoms. The study aims to uncover factors that contribute to Long COVID and improve prediction of who is at higher risk. Enrollment includes adults aged 18–75, both new participants and those with prior involvement.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 to 75 years.
* Previous laboratory-confirmed SARS-CoV-2 infection.
* Willing and able to provide informed consent.
* Able to complete study questionnaires and study procedures.

Exclusion Criteria:

* Current severe periodontal disease with bleeding gums.
* Current oral herpes flare, aphthous ulcer, or oral candidiasis (thrush).
* Oral viral or bacterial infection within the previous 30 days.
* Dry mouth that would prevent adequate saliva collection.
* Active alcohol or drug abuse.
* Medical or genetic syndrome or developmental delay that would prevent completion of study procedures or questionnaires.

Where it's running

• University of North Carolina
  Chapel Hill, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Laura Jacox, PhD, DMD, MS — University of North Carolina, Chapel Hill
• Study coordinator: Laura A Jacox, PhD, DMD, MS
• Email: ljacox@live.unc.edu
• Phone: +1 847-702-0988

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating antiviral treatments to prevent long-term heart issues after COVID-19

  This study is testing whether antiviral treatments like Paxlovid and Remdesivir can help prevent heart problems in adults who are hospitalized with COVID-19.

  Recruiting Phase 4 Mount Sinai Hospital, Canada · Kingston, Ontario and 3 other locations · NCT06792214

• Imaging neuroinflammation in patients with neurological issues after COVID-19 infection

  This study is testing a special imaging method to see if there is inflammation in the brains of people who have long-term symptoms after COVID-19, compared to healthy volunteers.

  Recruiting Early Phase 1 University of Alabama at Birmingham · Birmingham, Alabama · NCT05656105

• Light color therapy to help chronic pain

  This small crossover study tests whether colored light (S-cone chromatic light) can reduce pain in adults with fibromyalgia or chronic widespread pain compared with white light over two 7-day periods.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07825792

• Personalized PandA-tACS for Antenatal Depression

  This study tests whether a single personalized brain stimulation session can help pregnant people with depression more than a standard or sham stimulation.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07799480

• Melanin-Adjusted Blood Oxygen Sensor in ICU Patients

  This study tests a new pulse oximeter that adjusts for skin pigment to see if it gives accurate oxygen readings in ICU patients.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07799454

• Daily Upgrade: Can an essential amino acid supplement help active women improve body composition and metabolism?

  This study tests whether Daily Upgrade EAA+ helps healthy, active women by comparing it with whey protein and placebo before HIIT, and by using it daily for three weeks with twice-weekly HIIT workouts.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07792603

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.