Long-term follow-up of kidney disease patients after steroid treatment
Therapeutic Evaluation of STeroids in IgA Nephropathy Global - Post-Trial ObservatioNal Cohort Study
This study is looking at how a course of steroid treatment affects kidney health over the long term in people with end-stage kidney disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 366 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | The George Institute Academic / other |
| Locations | 58 sites (Kingswood, New South Wales and 57 other locations) |
| Trial ID | NCT05434325 on ClinicalTrials.gov |
What this trial studies
This observational study aims to extend the follow-up of participants from the original TESTING study to evaluate the long-term effects of a 6-9 month course of oral methylprednisolone on end-stage kidney disease (ESKD). It will assess outcomes based on different doses of the medication, ethnicity, and kidney function levels. The study seeks to determine whether the benefits of glucocorticoids are sustained over time and if a lower steroid dose can provide similar long-term kidney health benefits. Participants will be monitored for clinically important renal outcomes, including ESKD and changes in kidney function.
Who should consider this trial
Good fit: Ideal candidates are individuals who participated in the original TESTING trial and have not reached kidney failure requiring dialysis or transplantation.
Not a fit: Patients who have already reached kidney failure or have died during the original TESTING trial will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the long-term management of kidney diseases and the effectiveness of steroid treatments.
How similar studies have performed: Previous studies have shown promising results with glucocorticoid treatments in kidney disease, but this specific long-term follow-up approach is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1\) Only participants who were randomised into the TESTING trial Exclusion Criteria 1. Participants who have reached kidney failure requiring maintenance dialysis or kidney transplantation during the TESTING trial 2. Participants who died during the TESTING trial 3. Participants who had withdrawn their consent during the TESTING trial 4. Participants who are unable to provide consent for some other reason
Where this trial is running
Kingswood, New South Wales and 57 other locations
- Nepean Hospital — Kingswood, New South Wales, Australia (Recruiting)
- Royal North Shore Hospital — St Leonards, New South Wales, Australia (Recruiting)
- Royal Adelaide Hospital — Adelaide, South Australia, Australia (Recruiting)
- University of Calgary/Alberta Health Services — Calgary, Alberta, Canada (Not_yet_recruiting)
- University of Alberta Hospitals — Edmonton, Alberta, Canada (Recruiting)
- St Pauls Hospital — Vancouver, British Columbia, Canada (Not_yet_recruiting)
- St. Joseph's Healthcare — Hamiliton, Ontario, Canada (Not_yet_recruiting)
- London Health Sciences Centre — London, Ontario, Canada (Completed)
- Sunnybrook Health Sciences Centre — Toronto, Ontario, Canada (Recruiting)
- Toronto General Hospital, — Toronto, Ontario, Canada (Not_yet_recruiting)
- Hôpital Maisonneuve-Rosemont — Montreal, Quebec, Canada (Not_yet_recruiting)
- Chinese PLA General Hospital (301 Hospital) — Beijing, Beijing Municipality, China (Recruiting)
- The First Affiliated Hospital, Sun Yat-Sen University — Guangzhou, Guangdong, China (Not_yet_recruiting)
- Guangdong Provincial People's Hospital, Guangzhou — Guangzhou, Guangdong, China (Active_not_recruiting)
- Peking University Shenzhen Hospital — Shenzhen, Guangdong, China (Recruiting)
- The Second Hospital of Hebei Medical University — Shijiazhuang, Hebei, China (Recruiting)
- The Third Hospital of Hebei Medical University — Shijiazhuang, Hebei, China (Recruiting)
- The First Affiliated Hospital of Henan University of Science &Technology — Luoyang, Henan, China (Recruiting)
- The First Affiliated Hospital of Zhengzhou University — Zhengzhou, Henan, China (Not_yet_recruiting)
- Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology — Wuhan, Hubei, China (Not_yet_recruiting)
- Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China (Recruiting)
- Renmin Hospital, Wuhan University — Wuhan, Hubei, China (Not_yet_recruiting)
- The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, — Baotou, Inner Mongolia, China (Not_yet_recruiting)
- Inner Mongolia People's Hospital — Hohhot, Inner Mongolia, China (Recruiting)
- The First Affiliated Hospital with Nanjing Medical University — Nanjing, Jiangsu, China (Not_yet_recruiting)
- Jilin Province FAW General Hospital [Jilin University Fourth Hospital] — Changchun, Jilin, China (Not_yet_recruiting)
- he First Affiliated Hospital of Dalian Medical University, Dalian — Dalian, Liaoning, China (Not_yet_recruiting)
- Shengjing Hospital Of China Medical University — Shengyang, Liaoning, China (Recruiting)
- Qilu Hospital of Shandong University — Jinan, Shandong, China (Not_yet_recruiting)
- The First Affiliated Hospital of Shangdong First Medical University,Shangdong Provincial Qianfoshin — Jinan, Shandong, China (Recruiting)
- Shandong Provincial Hospital — Jinan, Shandong, China (Not_yet_recruiting)
- Jinan Military General Hospital — Jinan, Shandong, China (Not_yet_recruiting)
- The Second Hospital of Shanxi Medical University, Taiyuan — Taiyuan, Shanxi, China (Not_yet_recruiting)
- West China Hospital of Sichuan University — Chengdu, Sichuan, China (Recruiting)
- Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital — Chengdu, Sichuan, China (Not_yet_recruiting)
- The First Affiliated Hospital, Zhejiang University of Medicine — Hangzhou, Zhejiang, China (Not_yet_recruiting)
- Hangzhou Hospital of Traditional Chinese Medicine, — Hangzhou, Zhejiang, China (Recruiting)
- Ningbo Urology & Nephrology Hospital — Ningbo, Zhejiang, China (Not_yet_recruiting)
- Zhejiang Provincial People's Hospital — Sangzhou, Zhejiang, China (Recruiting)
- Beijing Anzhen Hospital, Capital Medical University — Beijing, China (Not_yet_recruiting)
- Peking University First Hospital — Beijing, China (Recruiting)
- Peking University People's Hospital — Beijing, China (Not_yet_recruiting)
- Peking University Third Hospital — Beijing, China (Not_yet_recruiting)
- XinQiao Hospital, Third Military Medical University — Chongqing, China (Recruiting)
- Renji Hospital, Shanghai Jiaotong University School of Medicine — Shanghai, China (Not_yet_recruiting)
- Ruijin Hospital, Shanghai Jiaotong University, School of Medicine — Shanghai, China (Not_yet_recruiting)
- Princess Margaret Hospital — Kowloon, Hong Kong (Completed)
- Osmania General Hospital — Hyderabad, Andhra Pradesh, India (Recruiting)
- Nizams Institute of Medical Sciences — Hyderabad, Andhra Pradesh, India (Not_yet_recruiting)
- Calicut Medical College — Kozhikode, Kerala, India (Recruiting)
+8 more sites — see ClinicalTrials.gov for the full list.
Study contacts
- Principal investigator: Muh Geot Wong, Dr — University of New Souht Wales
- Study coordinator: Rebecca Anderson
- Email: randerson@georgeinstitute.org.au
- Phone: +61401401440
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.