Long-term follow-up of individuals with mood disorders
Official title: Long-term Observation of Participants With Mood Disorders
Run by National Institutes of Health Clinical Center (CC) · NCT04877977 · Data updated 2026-11-12
This study looks at how mood disorders like depression and bipolar disorder affect people over time and gathers information to see how their mental health and treatments have changed.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 1 site (Bethesda, Maryland) |
| Status | Recruiting |
| Started | August 17, 2021 |
| Main results expected | October 1, 2028 |
| Study ends | October 1, 2028 |
| Registry record updated | October 1, 2026 |
| Trial ID | NCT04877977 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who previously consented to participate in a related protocol over a year ago.
✕Probably not a fit
Patients who have not previously participated in the related protocol or are under 18 years old may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the long-term impact of mood disorders, including depression and bipolar disorder, on participants who have previously engaged in research at the National Institute of Mental Health. Participants will complete online surveys and telephone assessments to evaluate their current mental health symptoms and treatments. The study will utilize existing clinical, biological, and neuroimaging data to identify predictors of long-term depressive symptoms, suicide attempts, and ketamine utilization. Additionally, it aims to track the incidence of premature death, including suicide, through linkage to national data sources.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the long-term management and treatment of mood disorders, potentially improving patient outcomes.
How similar studies have gone: Other studies have successfully utilized long-term observational approaches to understand mood disorders, making this a continuation of established research methodologies.
Who can join: the full rules
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Participants who signed consent for Protocol 01-M-0254: The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers over a year ago. 2. Age 18 years or older 3. Able to provide informed consent online using study website or over the telephone 4. Able to read and write English EXCLUSION CRITERIA: None.
Where it's running
-
National Institutes of Health Clinical Center
Bethesda, Maryland, United States Recruiting
Study contacts
- Principal investigator: Elizabeth D Ballard, Ph.D. — National Institute of Mental Health (NIMH)
- Study coordinator: Elizabeth D Ballard, Ph.D.
- Email: elizabeth.ballard@nih.gov
- Phone: (301) 435-9399
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.