Long-term follow-up after a year of regular exercise for people with symptomatic intracranial arterial stenosis
Official title: Regular Physical Exercise in Patients With Symptomatic Intracranial Arterial Stenosis: Three-year Follow-up of RESIST Trial
Run by Capital Medical University · NCT07242768 · Data updated 2026-11-12
This follow-up will see if benefits from a year of regular physical exercise last over three years for people with symptomatic intracranial arterial stenosis who completed the RESIST program.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 40 Years to 80 Years |
| Sex | All |
| Enrollment | 1300 (estimated) |
| Sponsor | Capital Medical University Academic / other |
| Locations | 1 site (Beijing) |
| Status | Recruiting |
| Started | January 10, 2026 |
| Main results expected | November 30, 2028 |
| Study ends | November 30, 2028 |
| Registry record updated | January 27, 2026 |
| Trial ID | NCT07242768 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are symptomatic ICAS patients who completed the 12-month RESIST trial follow-up and give written consent to continue for three more years of observation.
✕Probably not a fit
Patients who did not complete the RESIST trial, withdrew consent, were lost to follow-up at 12 months, or have conditions preventing follow-up visits are not eligible and would not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a non-interventional observational extension that follows participants who completed the 12-month RESIST exercise program to record clinical outcomes over the next three years. No additional interventions are given and routine clinical care continues while investigators collect data on recurrent ischemic events, functional status, cognition, quality of life, and other safety outcomes. The primary outcome is the incidence of new ischemic stroke within three years, with secondary endpoints including TIAs, hemorrhagic stroke, myocardial infarction, falls, all-cause death, modified Rankin Scale, cognitive screening, and EQ-5D-5L scores. Approximately 1,300 consenting RESIST completers will be followed at Xuanwu Hospital, Capital Medical University, with outcomes recorded until each participant reaches three years of follow-up.
Why it matters
Potential benefit: If successful, the results could show whether a year of regular exercise has lasting effects on reducing recurrent stroke and improving long-term function and quality of life in symptomatic ICAS patients.
How similar studies have gone: Exercise-based secondary prevention has shown benefits after stroke in broader populations, but long-term outcome data specifically for symptomatic intracranial arterial stenosis after a structured year-long program remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Participants who enrolled in the RESIST trial and completed the 12-month follow-up. 2. Written informed consent to participate in this 3-year observational extension. Exclusion Criteria: Participants who withdrew consent in the RESIST trial, decline to participate in this extension, or were lost to follow-up at 12 months.
Where it's running
-
Xuanwu Hospital, Capital Medical University
Beijing, China Recruiting
Study contacts
- Study coordinator: Xunming Ji
- Email: jixm@ccmu.edu.cn
- Phone: 01083198962
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
-
Non-contrast MRA vs Carotid Doppler for detecting carotid artery narrowing in stroke or TIA
This study tests whether non-contrast MRA can match or improve upon carotid Doppler in finding and grading carotid artery narrowing in adults with ischemic stroke or TIA.
-
Using Ticagrelor to Adjust Antiplatelet Therapy for Ischemic Stroke
This study is testing whether taking a lower dose of ticagrelor with aspirin for six months is better than a higher dose for one month in preventing more strokes in people who have had a non-disabling stroke or high-risk TIA.
-
Using mobile technology to manage cardiovascular risks in stroke patients
This study is testing if using mobile technology to monitor blood pressure and check for heart rhythm problems can help stroke patients manage their cardiovascular risks better than standard care.
-
Remote ischemic conditioning for post-stroke insomnia
A 136-person, randomized study will test whether a non-invasive arm-cuff procedure done twice daily for 90 days can improve sleep after a first ischemic stroke in adults 18–80.
-
Ear-based nerve stimulation to help sleep after a stroke
A device that delivers vagal nerve stimulation through the ear is tested to see if it helps stroke patients in rehab sleep better.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.