Long-term follow-up after a year of regular exercise for people with symptomatic intracranial arterial stenosis
Regular Physical Exercise in Patients With Symptomatic Intracranial Arterial Stenosis: Three-year Follow-up of RESIST Trial
This follow-up will see if benefits from a year of regular physical exercise last over three years for people with symptomatic intracranial arterial stenosis who completed the RESIST program.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1300 (estimated) |
| Ages | 40 Years to 80 Years |
| Sex | All |
| Sponsor | Capital Medical University Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT07242768 on ClinicalTrials.gov |
What this trial studies
This is a non-interventional observational extension that follows participants who completed the 12-month RESIST exercise program to record clinical outcomes over the next three years. No additional interventions are given and routine clinical care continues while investigators collect data on recurrent ischemic events, functional status, cognition, quality of life, and other safety outcomes. The primary outcome is the incidence of new ischemic stroke within three years, with secondary endpoints including TIAs, hemorrhagic stroke, myocardial infarction, falls, all-cause death, modified Rankin Scale, cognitive screening, and EQ-5D-5L scores. Approximately 1,300 consenting RESIST completers will be followed at Xuanwu Hospital, Capital Medical University, with outcomes recorded until each participant reaches three years of follow-up.
Who should consider this trial
Good fit: Ideal candidates are symptomatic ICAS patients who completed the 12-month RESIST trial follow-up and give written consent to continue for three more years of observation.
Not a fit: Patients who did not complete the RESIST trial, withdrew consent, were lost to follow-up at 12 months, or have conditions preventing follow-up visits are not eligible and would not benefit from participation.
Why it matters
Potential benefit: If successful, the results could show whether a year of regular exercise has lasting effects on reducing recurrent stroke and improving long-term function and quality of life in symptomatic ICAS patients.
How similar studies have performed: Exercise-based secondary prevention has shown benefits after stroke in broader populations, but long-term outcome data specifically for symptomatic intracranial arterial stenosis after a structured year-long program remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Participants who enrolled in the RESIST trial and completed the 12-month follow-up. 2. Written informed consent to participate in this 3-year observational extension. Exclusion Criteria: Participants who withdrew consent in the RESIST trial, decline to participate in this extension, or were lost to follow-up at 12 months.
Where this trial is running
Beijing
- Xuanwu Hospital, Capital Medical University — Beijing, China (Recruiting)
Study contacts
- Study coordinator: Xunming Ji
- Email: jixm@ccmu.edu.cn
- Phone: 01083198962
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.