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Long-term effects of Semaglutide in participants from the SELECT trial

SELECT-LIFE (SELECT Follow-up Study to Evaluate Long-term Impact oF Anti-obEsity Medication)

Observational Novo Nordisk A/S · NCT04972721

This study looks at the long-term effects of Semaglutide on people who took part in a previous trial to see how it impacts their health over the next ten years.

Quick facts

Study typeObservational
Enrollment3400 (estimated)
Ages45 Years and up
SexAll
SponsorNovo Nordisk A/S Industry-sponsored
Locations38 sites (Plainsboro, New Jersey and 37 other locations)
Trial IDNCT04972721 on ClinicalTrials.gov

What this trial studies

The SELECT-LIFE study is an observational study that aims to assess the long-term effects of Semaglutide in individuals who participated in the SELECT cardiovascular outcomes trial. Following the conclusion of the SELECT trial, participants will complete health questionnaires every six months for up to ten years to monitor their health outcomes. While no specific treatment will be provided during this study, participants will continue to receive standard care from their own healthcare providers. The study focuses on gathering data to better understand the lasting impacts of the medication on participants' health.

Who should consider this trial

Good fit: Ideal candidates are individuals who were randomized into the SELECT trial and have not withdrawn their consent.

Not a fit: Patients with mental incapacity, unwillingness, or language barriers that prevent adequate understanding or cooperation will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into the long-term health effects of Semaglutide for individuals with overweight and obesity.

How similar studies have performed: While this study builds on the findings of the SELECT trial, the long-term observational approach is relatively novel in this context.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Randomized into the SELECT clinical trial (EX9536-4388) and has not withdrawn consent, regardless of level of participation, dose achieved or treatment discontinuation.
* Signed SELECT-LIFE consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol).

Exclusion criteria:

* Mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation

Where this trial is running

Plainsboro, New Jersey and 37 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
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Conditions OverweightObesity
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.