Lokomat exoskeleton versus C‑Mill treadmill for improving walking after stroke
Official title: Comparative Study of Working With the LoKomat® Exoskeleton VS C-Mill® Treadmill for Gait Recovery in Rehabilitation and Improvement of Quality of Life in Adult Stroke Patients. Randomised Clinical Trial.
Run by Universidad Pontificia de Salamanca · NCT07230470 · Data updated 2026-11-12
This trial will test whether Lokomat exoskeleton therapy or C‑Mill treadmill training helps adults after stroke walk better and feel better in daily life.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Universidad Pontificia de Salamanca Academic / other |
| Locations | 1 site (Salamanca) |
| Status | Recruiting |
| Started | December 9, 2025 |
| Main results expected | February 25, 2026 |
| Study ends | June 20, 2026 |
| Registry record updated | May 4, 2026 |
| Trial ID | NCT07230470 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with a confirmed diagnosis of stroke who are cognitively able to give informed consent and have no contraindications to the robotic devices are ideal candidates.
✕Probably not a fit
Patients with severe cognitive impairment, other concomitant neurological diseases, disabling arthritis or osteoarthritis, or specific contraindications to the devices are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single‑center comparison enrolls adults with ischemic or hemorrhagic stroke who can consent and are eligible for robotic gait therapy. Participants receive a course of gait rehabilitation using either the Lokomat exoskeleton or the C‑Mill treadmill and are monitored in the neurorehabilitation clinic. Outcomes include objective gait measures (speed, balance), spasticity, and patient-reported quality of life measured before and after the intervention. Patients with major cognitive deficits, other neurologic disorders, or musculoskeletal problems that prevent safe device use are excluded.
Why it matters
Potential benefit: If successful, the intervention could help patients regain walking ability, reduce spasticity, and improve daily functioning and quality of life.
How similar studies have gone: Previous studies of both Lokomat and C‑Mill have shown improvements in gait speed, balance, and functional recovery in stroke patients, though direct comparative data are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of stroke (haemorrhagic and/or ischaemic) by a specialist physician. . * Subjects who are cognitively capable and who sign the informed consent form. Exclusion Criteria: * Severe cognitive impairment (Mini-Mental State Examination \< 24.), or impairment that prevents correct understanding of the correct understanding of the messages and explanatory orders of the treatment and its conditions. * Diagnosis of concomitant neurological diseases and craniocerebral trauma. cranioencephalic trauma. * Other diseases that interfere with the gait process (e.g. disabling arthritis or arthrosis, other neurological diseases, other neurological diseases). disabling arthritis or osteoarthritis, other concomitant neurological diseases, etc.). \- Contraindications of the robotic tools themselves.
Where it's running
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Universidad Pontificia de Salamanca
Salamanca, Spain Recruiting
Study contacts
- Study coordinator: Jorge V Velázquez Saornil, PhD.
- Email: jvelazquezsa@upsa.es
- Phone: 655909940
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Deep phenotyping to explore recovery in young adults after stroke
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
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This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
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This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.
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Remote Ischaemic Conditioning for Fatigue After Stroke 2
Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.
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Dual-task balance training plus computer-based cognitive training after stroke
In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.