Clinical trial Recruiting at 1 site Interventional Ages 18 to 65

Lokomat exoskeleton versus C‑Mill treadmill for improving walking after stroke

Official title: Comparative Study of Working With the LoKomat® Exoskeleton VS C-Mill® Treadmill for Gait Recovery in Rehabilitation and Improvement of Quality of Life in Adult Stroke Patients. Randomised Clinical Trial.

Run by Universidad Pontificia de Salamanca · NCT07230470 · Data updated 2026-11-12

This trial will test whether Lokomat exoskeleton therapy or C‑Mill treadmill training helps adults after stroke walk better and feel better in daily life.

More Stroke trials

Quick facts

Study typeInterventional
Ages18 Years to 65 Years
SexAll
Enrollment40 (estimated)
SponsorUniversidad Pontificia de Salamanca
Academic / other
Locations1 site (Salamanca)
StatusRecruiting
StartedDecember 9, 2025
Main results expectedFebruary 25, 2026
Study endsJune 20, 2026
Registry record updatedMay 4, 2026
Trial IDNCT07230470 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with a confirmed diagnosis of stroke who are cognitively able to give informed consent and have no contraindications to the robotic devices are ideal candidates.

Probably not a fit

Patients with severe cognitive impairment, other concomitant neurological diseases, disabling arthritis or osteoarthritis, or specific contraindications to the devices are unlikely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single‑center comparison enrolls adults with ischemic or hemorrhagic stroke who can consent and are eligible for robotic gait therapy. Participants receive a course of gait rehabilitation using either the Lokomat exoskeleton or the C‑Mill treadmill and are monitored in the neurorehabilitation clinic. Outcomes include objective gait measures (speed, balance), spasticity, and patient-reported quality of life measured before and after the intervention. Patients with major cognitive deficits, other neurologic disorders, or musculoskeletal problems that prevent safe device use are excluded.

Why it matters

Potential benefit: If successful, the intervention could help patients regain walking ability, reduce spasticity, and improve daily functioning and quality of life.

How similar studies have gone: Previous studies of both Lokomat and C‑Mill have shown improvements in gait speed, balance, and functional recovery in stroke patients, though direct comparative data are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of stroke (haemorrhagic and/or ischaemic) by a specialist physician. .
* Subjects who are cognitively capable and who sign the informed consent form.

Exclusion Criteria:

* Severe cognitive impairment (Mini-Mental State Examination \< 24.), or impairment that prevents correct understanding of the correct understanding of the messages and explanatory orders of the treatment and its conditions.
* Diagnosis of concomitant neurological diseases and craniocerebral trauma. cranioencephalic trauma.
* Other diseases that interfere with the gait process (e.g. disabling arthritis or arthrosis, other neurological diseases, other neurological diseases).

disabling arthritis or osteoarthritis, other concomitant neurological diseases, etc.).

\- Contraindications of the robotic tools themselves.

Where it's running

  • Universidad Pontificia de Salamanca
    Salamanca, Spain
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.