Liquid fibrin versus soft laser to improve healing and reduce relapse after lip repositioning for gummy smile

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Lip repositioning surgery reduces excessive gingival display but can be complicated by pain, swelling, delayed healing, and postoperative relapse. In this single-center interventional trial at Damascus University, patients with a gummy smile due to hyperactive upper lip will undergo lip repositioning and be assigned to receive either injectable liquid platelet-rich fibrin (i-PRF) or low-level soft laser therapy as an adjunct. The study will track wound healing, pain and swelling, and the degree of gingival display relapse over follow-up visits. The two adjunctive approaches will be compared to determine which better supports tissue healing and stability of the surgical result.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients of both genders.
2. Patients presenting with a gummy smile in the maxillary anterior region (more than 3 mm) due to upper lip hypermobility.
3. Age 18-50 years.
4. Systemically healthy individuals, classified as ASA physical status I or II according to the American Society of Anesthesiologists (ASA) classification; that is, patients without systemic disease or with mild, well-controlled systemic conditions.
5. Patients with good oral hygiene, defined as an O'Leary Plaque Index ≤ 40%.
6. No previous lip repositioning surgery.

Exclusion Criteria:

1. Pregnancy and lactation.
2. Individuals with a previous history of receiving facial Botox or filler injections.
3. Systemic diseases or conditions that contraindicate the use of local anesthesia.
4. Any physical condition that impairs the ability to perform proper oral hygiene measures.
5. Patients who are smokers or alcohol consumers.
6. Inability or unwillingness to cooperate.
7. In adequate width of attached gingiva.
8. Vertical maxillary excess (moderate to severe) requiring orthognathic intervention.
9. Short upper lip
10. Gingival display primarily caused by altered passive eruption requiring crown lengthening.

Where it's running

• Faculty of Dentistry, Damascus university , Syria.
  Damascus, Rif-dimashq Governorate, Syria Recruiting

Study contacts

• Study coordinator: Tarek Qasem, DDS MSc PhD
• Email: Tarek2.qasem@damascusuniversity.edu.sy
• Phone: +963 933432778

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• AI-assisted measurement of gummy smiles from photos

  A computer program using artificial intelligence will try to identify and measure gummy smiles from patient photos to see if its measurements match those of expert dentists.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07759843

• Using AI to analyze gummy smiles

  This study is testing a new AI tool to see if it can help dentists better understand and analyze gummy smiles by looking at pictures of them.

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• Assessing a new technique for measuring gum tissue changes in aesthetic dentistry

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  Recruiting British University In Egypt · Cairo · NCT06673576

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.