Liquid biopsy in cartilaginous bone tumors to help diagnose and monitor chondrosarcoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study investigates whether liquid biopsy biomarkers, including IDH1/2 mutations and cytokine profiles, can aid in diagnosing intermediate to malignant cartilaginous tumors and in monitoring disease alongside or as an alternative to imaging. Patients with semimalignant or malignant cartilaginous tumors who undergo surgery are eligible. The study analyzes laboratory biomarker data and molecular pathology from blood samples collected over time to explore correlations with tumor characteristics and outcomes. It aims to improve timely diagnosis, prognosis estimation, and recurrence detection while reducing reliance on cost-intensive, radiation-exposing imaging. The exact primary questions are not fully detailed in the available description.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Semimalignant or malignant cartilaginous tumour (atypical cartilaginous tumour, chondrosarcoma G1/2/3, dedifferentiated chondrosarcoma)
* Definite surgery of primary tumour

Exclusion Criteria:

* Prior tumour-specific treatment (except for biopsy)

Where it's running

• Department of Orthopaedics and Trauma
  Graz, Styria, Austria Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.