Liposomal versus standard bupivacaine for thoracic paravertebral block after thoracoscopic lobectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults undergoing unilateral thoracoscopic lobectomy receive ultrasound-guided thoracic paravertebral blocks at T4-5, T6-7, and T8-9 with set volumes of local anesthetic. One group receives a mixture of 10 mL 1.33% liposomal bupivacaine (133 mg) plus 10 mL 0.5% bupivacaine hydrochloride, while the control group receives 20 mL 0.5% bupivacaine hydrochloride (100 mg). All patients have standardized total intravenous anesthesia and intraoperative monitoring, and postoperative pain control and safety are tracked to compare analgesic effect and adverse events. The protocol is designed to determine whether the liposomal formulation provides noninferior or improved postoperative analgesia compared with standard bupivacaine.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\) Age ≥18 years old;

  2\) Patients undergoing unilateral initial thoracoscopic lobectomy under general anesthesia (TV or robot-assisted);

  3\) American Society of Anesthesiologists (ASA) Grade I - III;

  4\) Voluntarily participate in the study and sign the informed consent.

Exclusion Criteria:

* 1\) Pregnant or lactating women;

  2\) Pulmonary wedge-shaped resection;

  3\) ≥2 thoracic drainage tubes;

  4\) Abnormal liver function: ALT and/or AST\>2×ULN, or

TBIL≥1.5×ULN;

5\) Renal function impairment (serum creatinine \>176μmol/L), or received dialysis treatment within 28 days before surgery;

6\) Participate in another research trial involving an investigational drug within 6 months;

7\) A history of drug or alcohol abuse;

8\) Long-term use of opioids (more than 3 months or more than 5 mg daily morphine equivalent per day for 1 month);

9\) History of allergy to local anesthetics or one of the investigational drugs;

10\) Uncontrolled mental or neurological symptoms.

Where it's running

• Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University
  Jinan, Shandong, China Recruiting

Study contacts

• Study coordinator: yong t Sun, PH.D
• Email: sunyongtao1979@163.com
• Phone: 18660795201

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.