Lipids, PyroEVs, and PLIN3 in sepsis endothelial injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study enrolls sepsis patients meeting Sepsis 3.0 criteria admitted to Zhongda Hospital ICU, plus healthy volunteers. It examines the association between PyroEVs and PLIN3 with organ failure and prognosis over 28 days. This is an observational cohort with no experimental treatment. The primary outcomes include 28-day mortality and SOFA score trajectories. The study aims to identify biomarkers that may reflect endothelial injury and sepsis severity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* a. Presence of confirmed or suspected infection; b. Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline; c. Signed informed consent.

Exclusion Criteria:

* Age \< 18 or \> 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury.

Where it's running

• Zhongda Hospital, Southeast University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Yi Yang — Zhongda Hospital
• Study coordinator: Fei Peng, Dr. PhD.
• Email: afei0312@163.com
• Phone: 15950565786

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.