Linking EEG brain activity and pathology in Lewy body disease
Dynamical Electrophysiology and Neuropathology in Lewy's Bodies Disease
This project will test whether distinct EEG activity patterns can help identify and explain Lewy body disease in adults who had prior EEGs and RT-QuIC testing.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Trial ID | NCT07335692 on ClinicalTrials.gov |
What this trial studies
This is an observational, retrospective analysis of adults from the Alpha-Lewy-MA cohort who underwent RT-QuIC testing and a standard EEG at the University Hospital of Strasbourg between 2012 and 2020. Researchers will analyze EEG dynamics to see if characteristic abnormalities correlate with RT-QuIC results and neuropathological features of Lewy body disease. The goal is to confirm that observed EEG phenomena are linked to disease pathophysiology and to more precisely characterize those brain dynamics. No new interventions are administered; the work uses existing clinical and electrophysiological data.
Who should consider this trial
Good fit: Adults (≥18) from the Alpha-Lewy-MA cohort who had RT-QuIC analysis and a standard EEG performed at HUS between January 1, 2012 and January 1, 2020, and who do not oppose participation.
Not a fit: Patients without prior RT-QuIC or an EEG from the specified HUS time window, patients under 18, or those who declined participation are not eligible and would not benefit from this analysis.
Why it matters
Potential benefit: If successful, the findings could lead to EEG-based markers that improve earlier and more accurate diagnosis and understanding of Lewy body disease.
How similar studies have performed: Previous studies have reported EEG abnormalities in Lewy body disease but the approach remains exploratory and no widely accepted EEG diagnostic test has been established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult subjects (≥18 years old). * Subject who participated in the Alpha-Lewy-MA cohort and underwent RT-QuIC analysis. * Subject who underwent a standard EEG examination at HUS between January 1, 2012, and January 1, 2020. Exclusion Criteria: \- Subject who expressed opposition to participating in the study.
Where this trial is running
Strasbourg
- Service de psychiatrie de la personne âgée - CHU de Strasbourg - France — Strasbourg, France (Recruiting)
Study contacts
- Study coordinator: Ludovic DORMEGNY-JEANJEAN, MD
- Email: ludovic.jeanjean@chru-strasbourg.fr
- Phone: 33 3 88 11 69 21
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.