Linking EEG brain activity and pathology in Lewy body disease
Official title: Dynamical Electrophysiology and Neuropathology in Lewy's Bodies Disease
Run by University Hospital, Strasbourg, France · NCT07335692 · Data updated 2026-11-12
This project will test whether distinct EEG activity patterns can help identify and explain Lewy body disease in adults who had prior EEGs and RT-QuIC testing.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Status | Recruiting |
| Started | June 2, 2025 |
| Main results expected | June 2026 |
| Study ends | June 2, 2026 |
| Registry record updated | January 13, 2026 |
| Trial ID | NCT07335692 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) from the Alpha-Lewy-MA cohort who had RT-QuIC analysis and a standard EEG performed at HUS between January 1, 2012 and January 1, 2020, and who do not oppose participation.
✕Probably not a fit
Patients without prior RT-QuIC or an EEG from the specified HUS time window, patients under 18, or those who declined participation are not eligible and would not benefit from this analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational, retrospective analysis of adults from the Alpha-Lewy-MA cohort who underwent RT-QuIC testing and a standard EEG at the University Hospital of Strasbourg between 2012 and 2020. Researchers will analyze EEG dynamics to see if characteristic abnormalities correlate with RT-QuIC results and neuropathological features of Lewy body disease. The goal is to confirm that observed EEG phenomena are linked to disease pathophysiology and to more precisely characterize those brain dynamics. No new interventions are administered; the work uses existing clinical and electrophysiological data.
Why it matters
Potential benefit: If successful, the findings could lead to EEG-based markers that improve earlier and more accurate diagnosis and understanding of Lewy body disease.
How similar studies have gone: Previous studies have reported EEG abnormalities in Lewy body disease but the approach remains exploratory and no widely accepted EEG diagnostic test has been established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult subjects (≥18 years old). * Subject who participated in the Alpha-Lewy-MA cohort and underwent RT-QuIC analysis. * Subject who underwent a standard EEG examination at HUS between January 1, 2012, and January 1, 2020. Exclusion Criteria: \- Subject who expressed opposition to participating in the study.
Where it's running
-
Service de psychiatrie de la personne âgée - CHU de Strasbourg - France
Strasbourg, France Recruiting
Study contacts
- Study coordinator: Ludovic DORMEGNY-JEANJEAN, MD
- Email: ludovic.jeanjean@chru-strasbourg.fr
- Phone: 33 3 88 11 69 21
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.