Linking autonomic nervous system function to acute graft-versus-host disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort of HLA-haploidentical hematopoietic transplant recipients aged over 16. Researchers will monitor autonomic nervous system (ANS) function around the transplant period using physiological measurements and apply a predictive model to classify risk of acute graft-versus-host disease (aGvHD). No interventional treatments are assigned; clinical care follows standard practice while data are collected. The aim is to determine whether changes in ANS signals precede or correlate with aGvHD onset and could support earlier detection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients must be \> 16 years of age;
2. Patients receiving HLA-haploidentical transplants;
3. Patients have to sign an informed consent form before the start of the research procedure.

Exclusion Criteria:

1. Tandem transplantation or multiple transplantations;
2. Mental or other medical conditions that make the patients unable to comply with the research treatment and monitoring requirements;
3. Patients who are ineligible for the study due to other factors, or will bear great risk if participating in the study.

Where it's running

• Institute of Hematology & Blood Diseases Hospital
  Tianjin, Tianjin Municipality, China Recruiting

Study contacts

• Study coordinator: Yahui Feng
• Email: fengyahui@ihcams.ac.cn
• Phone: 022-23608045

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.