Link between sinusitis and age-related macular degeneration
Official title: Detection and Management of Sinusitis in a Single-center Prospective Cohort of Patients With Exudative AMD (SINE)
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT05547633 · Data updated 2026-11-12
This study is trying to see if treating sinusitis can help people with age-related macular degeneration need fewer eye injections.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | January 20, 2023 |
| Main results expected | January 2027 |
| Study ends | April 2028 |
| Registry record updated | December 10, 2025 |
| Trial ID | NCT05547633 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with bilateral neovascular AMD who have received multiple intravitreal injections in the past year.
✕Probably not a fit
Patients with severe myopia, those already treated for sinusitis, or with specific retinal conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the relationship between sinusitis and age-related macular degeneration (AMD) by assessing patients with exudative AMD at the Fondation Adolphe de Rothschild Hospital. The study will involve screening for sinusitis in patients who have been treated for bilateral neovascular AMD for at least two years. Investigators will evaluate whether treating sinusitis may lead to a reduction in the need for anti-VEGF injections, suggesting a potential inflammatory link between the two conditions.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with AMD by addressing underlying sinusitis.
How similar studies have gone: While the link between sinusitis and AMD is being explored, this specific approach is novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Patient followed and treated for at least 2 years for bilateral neovascular form of age-related macular degeneration (AMD) * At least one eye treated with ≥ 6 intravitreal injections during the year preceding preinclusion * Express consent to participate in the study * Affiliated with or beneficiary of a social security plan Exclusion Criteria: * Persons referred to in articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of liberty by judicial or administrative decision, minors, and persons under legal protection: guardianship or curatorship). * Severe myopia (\> 6 diopters) * Patient already being treated for acute or chronic sinusitis * History of central serous chorioretinopathy or diffuse retinal epitheliopathy
Where it's running
-
Hôpital Fondation A. de Rothschild
Paris, France Recruiting
Study contacts
- Study coordinator: Amélie Yavchitz
- Email: ayavchitz@for.paris
- Phone: +33148036454
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.