Link between lung pressure and fluid in patients with ARDS
Association Between Driving Transpulmonary Pressure and Extravascular Lung Water in Patients with ARDS
This study looks at how lung pressure and fluid levels are connected in patients with acute respiratory distress syndrome (ARDS) who are on a ventilator.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Bicetre Hospital Academic / other |
| Locations | 1 site (Le Kremlin-Bicêtre) |
| Trial ID | NCT05474196 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between driving transpulmonary pressure and extravascular lung water in patients suffering from acute respiratory distress syndrome (ARDS). It focuses on intubated patients who are monitored using a transpulmonary thermodilution device and esophageal pressure monitoring. By understanding how these pressures correlate, the study aims to provide insights into ventilatory induced lung injury and pulmonary edema in ARDS patients.
Who should consider this trial
Good fit: Ideal candidates for this study are intubated patients diagnosed with acute respiratory distress syndrome who are being monitored with specific devices.
Not a fit: Patients with legal protection measures, pregnancy, or contraindications for esophageal catheterization may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the management of ARDS by providing better insights into lung injury and fluid management.
How similar studies have performed: While this approach is novel in its specific focus, similar studies have explored the relationship between lung pressures and fluid management in ARDS, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Acute respiratory distress syndrome (ARDS) * Monitoring with a transpulmonary thermodilution device * Esophageal pressure monitoring Exclusion Criteria: * Legal protection measures * Pregnancy * Contra-indications of esophageal catheter : esophageal varicose, severe coagulopathy
Where this trial is running
Le Kremlin-Bicêtre
- Medical Intensive Care Unit, Bicêtre Hospital — Le Kremlin-Bicêtre, France (Recruiting)
Study contacts
- Principal investigator: Tài Pham, MD, PhD — Hôpital Bicêtre
- Study coordinator: Tài Pham, MD, PhD.
- Email: tai.pham@aphp.fr
- Phone: +33145217245
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.