Lifestyle interventions for early onset Alzheimer's disease
Official title: Lifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease Study
Run by Indiana University · NCT05573490 · Data updated 2026-11-12
This study is testing if a mix of brain training on a computer and Tai Chi-Qi Gong exercises can help people with early-onset Alzheimer's feel better and improve their thinking and mood.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 75 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Indiana University Academic / other |
| Locations | 1 site (Indianapolis, Indiana) |
| Status | Recruiting |
| Started | January 11, 2024 |
| Main results expected | June 2028 |
| Study ends | June 2028 |
| Registry record updated | May 6, 2026 |
| Trial ID | NCT05573490 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged 40-64 who have been diagnosed with amyloid-positive Early-Onset Alzheimer's Disease and are enrolled in the Longitudinal Early-Onset AD Study.
✕Probably not a fit
Patients who do not have access to the internet for at least 4 hours per week may not benefit from this study due to the nature of the interventions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of a combined approach of computerized cognitive training and Tai Chi-Qi Gong exercise for individuals diagnosed with Early-Onset Alzheimer's Disease (EOAD). Participants will undergo cognitive, functional, and mood assessments before being randomized into either the intervention group or an active control group. The study will assess the feasibility of the intervention and measure its impact on cognition, functioning, and mood at both immediate post-treatment and six-month follow-up intervals. Additionally, it will explore how individual differences may influence the benefits derived from the intervention.
Why it matters
Potential benefit: If successful, this study could provide new insights into non-pharmacological interventions that improve cognitive function and quality of life for patients with early onset Alzheimer's disease.
How similar studies have gone: While this approach is innovative, similar studies focusing on lifestyle interventions for cognitive improvement in Alzheimer's patients have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Enrolled in the Longitudinal Early-Onset AD Study (LEADS) parent study, and being classified via LEADS consensus criteria as having amyloid-positive Early Onset Alzheimer's Disease * Aged 40-64 years at the time of enrollment into LEADS * Fluent in English * In good general health and absent another neurological disorder * Have a knowledgeable informant. * Have had a Clinical Dementia Rating scale of 0.5 to 1.0 at the time of enrollment into LEADS * Have sufficient vision, hearing, comprehension, and manual dexterity to participate in the testing and training program Exclusion Criteria: • Have access to the internet (e.g., home, family, public library, etc.) for less than 4 hours per week
Where it's running
-
Indiana University
Indianapolis, Indiana, United States Recruiting
Study contacts
- Principal investigator: Dustin B Hammers, PhD — Indiana University
- Study coordinator: Dustin B Hammers, PhD
- Email: hammersd@iu.edu
- Phone: 3179638557
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.