Lifestyle changes to improve fitness and immune function in chronic kidney disease patients
Effect of Lifestyle Intervention in Patients With Chronic Kidney Disease on Fitness and Immune Function
NA · Chang Gung Memorial Hospital · NCT05649657
This study is testing whether a 6-month program of exercise and diet changes can help people with chronic kidney disease feel fitter and boost their immune system.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 160 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | Chang Gung Memorial Hospital (other) |
| Locations | 1 site (Taoyuan) |
| Trial ID | NCT05649657 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of a 6-month lifestyle intervention for patients with chronic kidney disease (CKD) stages 3-5. A total of 120 participants will undergo a self-controlled trial, which includes a 3-month control phase, a 6-month intervention phase, and a 3-month maintenance phase, with no interventions during the control and maintenance periods. The intervention will involve a multidisciplinary team providing exercise training and dietary guidance, focusing on improving physical fitness and immune function. Additionally, participants in earlier stages of CKD and healthy subjects will be assessed for baseline fitness and immune function without receiving any intervention.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with chronic kidney disease in stages 3-5 who have been on hemodialysis for more than 6 months and are stable during dialysis.
Not a fit: Patients with unstable cardiac conditions or those with comorbidities that contraindicate exercise may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could enhance physical fitness and immune response in patients with chronic kidney disease, potentially improving their overall health and quality of life.
How similar studies have performed: Previous studies have shown that exercise training can significantly benefit patients with chronic kidney disease, suggesting that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients with CKD in stages 3-5 * patients who are on HD for longer than 6 months * under the permission of their nephrologist * adequately dialyzed (most recent Kt/V \> 1.2) and stable during dialysis in the past 3 months Exclusion Criteria: * occurrence of hyperkalemia in the past 3 months * comorbid medical, physical, and mental conditions that contraindicate exercise * unstable cardiac conditions (eg, unstable angina, heart failure or symptomatic severe aortic stenosis, etc.) * disabling orthopedic and neuromuscular diseases
Where this trial is running
Taoyuan
- Chang Gung Memorial Hospital — Taoyuan, Taiwan (RECRUITING)
Study contacts
- Principal investigator: Shu-Chun Huang, MD, PhD — Chang Gung Memorial Hospital
- Study coordinator: Shu-Chun Huang, MD, PhD
- Email: mr7171@cgmh.org.tw
- Phone: +8863281200
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Chronic Kidney Diseases