Lidocaine's effects on pain and survival in elderly colorectal surgery patients
Effect of Perioperative Continuous Intravenous Infusion of Lidocaine on Postoperative Pain and Long-term Survival in Elderly Patients Undergoing Colorectal Cancer Surgery: a Prospective, Randomized Controlled Trial
This study is testing if giving lidocaine during colorectal surgery can help older patients manage pain better, improve their quality of life, and live longer after the surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 276 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | West China Hospital Academic / other |
| Locations | 1 site (Sichuan) |
| Trial ID | NCT06405776 on ClinicalTrials.gov |
What this trial studies
This study evaluates the impact of long-term lidocaine infusion on postoperative chronic pain, quality of life, and survival rates in elderly patients undergoing colorectal cancer surgery. Participants aged 60 and older will be randomized into two groups: one receiving lidocaine and the other receiving a placebo during surgery. The lidocaine group will receive a continuous infusion of lidocaine throughout the procedure, followed by a postoperative analgesia pump. Follow-up assessments will track chronic pain, quality of life, and survival outcomes over a period of up to five years.
Who should consider this trial
Good fit: Ideal candidates are elderly patients aged 60 and older scheduled for elective colorectal surgery with an ASA physical status of I to III.
Not a fit: Patients with metastatic cancer, severe hepatic or renal impairment, or significant cardiac issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce postoperative pain and improve long-term survival for elderly patients undergoing colorectal surgery.
How similar studies have performed: Previous studies have shown promising results with lidocaine in postoperative pain management, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Participants were at least 60 years old; 2. American Society of Anesthesiologists (ASA) physical status I to III; 3. Body-mass index of 18-30 kg/m2; 4. Scheduled for elective colorectal surgery. Exclusion Criteria: 1. Metastases occurring in other distant organs; 2. Severe hepatic insufficiency (aspartate aminotransferase or alaninetransaminase or bilirubin \>2.5 times the upper limit of normal); 3. Renal impairment (creatinine clearance \<60 mL/min); 4. Cardiac rhythm disorders or systolic heart failure (second-and thirddegree heart block, ejection fraction \<50%); 5. Allergies to any of the trial drugs; chronic opioid use; 6. Inability to comprehend numeric rating scale.
Where this trial is running
Sichuan
- China — Sichuan, China (Recruiting)
Study contacts
- Study coordinator: Chunling Jiang, PhD
- Email: jiang_chunling@yahoo.com
- Phone: 18980601096
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.