Levothyroxine for heart function in children with subclinical hypothyroidism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Children with subclinical hypothyroidism (elevated TSH with normal free T4 and FT3) will receive levothyroxine and undergo repeated cardiac evaluations to see how treatment affects heart function. Eligibility requires stable elevated TSH (≥4.5 mIU/L) confirmed 4–6 weeks apart and excludes obesity, hypertension, prior thyroid or cardiac drug use, and known heart, liver, kidney, metabolic, infectious, respiratory, or malignant disease. Cardiac outcomes will be monitored with clinical exams and imaging or functional cardiac tests at the treating center, alongside thyroid function monitoring. The intervention is administered at Tanta University and follows an interventional protocol to compare pre- and post-treatment cardiac measures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 4 to 15 years.
* Both sexes.
* Patients with stable elevated thyroid-stimulating hormone (TSH) ≥ 4.5 mIU/L with normal free T4 and ft3 in different measurement 4 - 6 weeks apart.

Exclusion Criteria:

* Overweight and obesity
* Hypertension
* Previous use of levothyroxine, antiepileptic drugs, or cardiac drugs within the last 6 months.
* Arrhythmia.
* Congenital or acquired heart disease
* Liver or kidney disease
* Hyperlipidemia
* Diabetes
* Infectious diseases
* Respiratory diseases
* Malignancies

Where it's running

• Tanta University
  Tanta, El-Gharbia, Egypt Recruiting

Study contacts

• Study coordinator: Zeinab E Elshareef, MBBCH
• Email: zeinabibraheem26@gmail.com
• Phone: 00201001700194

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.