Effects of different types of dietary fat on liver and heart health
The Effect of Short-term Overconsumption of Specific Dietary Nutrients on Liver and Adipose Tissue Metabolism.
This study tests how eating different types of fats affects liver and heart health in healthy adults over 28 days.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 26 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University of Oxford Academic / other |
| Locations | 1 site (Oxford) |
| Trial ID | NCT05962190 on ClinicalTrials.gov |
What this trial studies
This study investigates how the consumption of saturated versus unsaturated fatty acids affects liver fat, cardiac function, and metabolism in healthy adults. Participants will follow a high-fat diet for 28 days, with assessments including MRI scans to measure liver and cardiac fat, as well as metabolic responses to a test meal. The goal is to understand the impact of dietary fat composition on metabolic health without changes in body weight.
Who should consider this trial
Good fit: Ideal candidates are healthy men and women aged 18 to 65 with a stable body weight and a BMI between 19 and 35.
Not a fit: Patients with metabolic conditions, significant weight fluctuations, or those on relevant drug therapies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into dietary recommendations for improving liver and heart health.
How similar studies have performed: Previous studies have explored dietary fat impacts on metabolism, but this specific comparison of saturated and unsaturated fats in a controlled setting is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The participant is willing and able to give informed consent for participation in the study. * Male or Female, aged ≥18 or ≤65 years. * Body Mass Index ≥19 ≤35 kg/m2 * No medical condition or relevant drug therapy that is known to affect liver or adipose tissue metabolism. * Weight stable for the previous 3 months Exclusion Criteria: * The participant is unwilling or unable to give informed consent for participation in the study. - Aged ≤18 or ≥65 years * Body Mass Index ≤19 or ≥35kg/m2 * Blood haemoglobin \<135mg/dL for men and \<120mg/dL for women * Donated (or lost) ≥250 ml of blood in the previous two months. * On a weight loss diet or have decreased their body weight by \>5% in the previous 3 months. * Have increased their body weight by \>5% in the previous 3 months. * Any metabolic condition or relevant drug therapy * Current smoker * History of alcoholism or a greater than recommended alcohol intake (\>30 g of alcohol daily for men and \>20 g of alcohol daily for women) * Haemorrhagic disorders * Anticoagulant treatment * History of albumin allergy * Pregnant or nursing mothers * Women prescribed any contraceptive agent or device including oral contraceptives, hormone replacement therapy (HRT) or who have used these within the last 12 months History of severe claustrophobia * Presence of metallic implants, pacemakers, or are unwilling to remove any piercings * History of an eating disorder or any other psychological condition that may affect the participant's ability to adhere to study intervention/experimental diets.
Where this trial is running
Oxford
- Oxford Centre for Diabetes, Endocrinology and Metabolism — Oxford, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Leanne Hodson, PhD — University of Oxford
- Study coordinator: Leanne Hodson
- Email: leanne.hodson@ocdem.ox.ac.uk
- Phone: 01865 857224
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.