Lesion-tailored, fundus-controlled testing in geographic atrophy on pegcetacoplan

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective study follows adults with geographic atrophy due to AMD who are treated with pegcetacoplan in real-world clinic settings. Participants undergo repeated vision testing, imaging, and questionnaires over 24 months to see if lesion-tailored fundus-controlled perimetry detects functional changes near atrophy. Standard tests include BCVA, FCP with training and pattern variations, and imaging such as FAF, NIR, SD-OCT, with optional color photos and OCT-A. Data collected cover medical history, medications, lifestyle, and demographics to support analysis of functional and imaging correlations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 65-90 years.
* Geographic Atrophy (GA) secondary to dry Age-related Macular Degeneration (AMD) in at least one eye with the following criteria:

  * GA lesion size between 1 and 15 mm² (≈ 0.4 to 6 disc areas)
  * GA borders must be at least 500 μm from the edge of the 30° × 25° optical coherence tomography (OCT) image frame
  * No confluent GA extending into peripapillary atrophy
* Receiving intravitreal pegcetacoplan per label (at least one injection before screening).
* Best-corrected visual acuity (BCVA) of 0.1 - 1.0 logMAR (≈ 20/20 to 20/200 Snellen)
* Able to undergo mesopic FCP and required imaging.
* Informed consent provided.

Exclusion Criteria:

* Currently or previously active exudative macular neovascularization in the study eye.
* High refractive errors (\> ±5.00 Diopters \[D\] spherical equivalent) and significant astigmatism (\> 2.50 D).
* Ocular comorbidities likely to confound sensitivity or imaging (e.g., diabetic retinopathy with macular edema, retinal vein occlusion (RVO), inherited retinal disease, uncontrolled glaucoma).
* Media opacity precluding reliable fundus-controlled perimetry (FCP) or imaging (e.g., dense cataract, corneal opacity, vitreous hemorrhage).
* Any systemic condition judged likely to compromise participation, follow-up, or data integrity.

Where it's running

• University of Utah, Department of Ophthalmology, John A. Moran Eye Center
  Salt Lake City, Utah, United States Recruiting

Study contacts

• Principal investigator: Monika Fleckenstein, MD — University of Utah, Department of Ophthalmology
• Study coordinator: Jenny Mireles
• Email: jenny.mireles@utah.edu
• Phone: +1

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.