Leptin Levels in Children With Adenoid/Adenotonsillar Hypertrophy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study compares serum and salivary leptin levels in children aged 3–18 with adenoid or adenotonsillar hypertrophy to age- and sex-matched controls without hypertrophy. Leptin, an appetite-regulating hormone, is measured in fasting morning samples using ELISA, and relationships with height, weight, and BMI are analyzed. The goal is to see if saliva leptin reflects serum leptin and whether leptin levels relate to growth metrics in the two groups. Statistical tests will include t-tests or nonparametric equivalents and correlation analyses. Participants are recruited from the Harran University Faculty of Medicine Hospital, with 40 in each group.

Why it matters

Who can join: the full rules

Adenoid/Adenotonsillar Hypertrophy Group

Inclusion Criteria:

* Age 3 to 18 years
* Diagnosis of adenoid hypertrophy or adenoid and palatine tonsil hypertrophy at the Otorhinolaryngology outpatient clinic by clinical examination with or without endoscopic evaluation
* Stable general condition without known chronic systemic disease
* No medical contraindication to venous blood and saliva sampling
* Written informed consent obtained from a parent or legal guardian

Exclusion Criteria:

* Signs of acute upper or lower respiratory tract infection at the time of sampling or within the previous 2 weeks
* Chronic endocrine, metabolic, cardiac, renal, hepatic or hematologic systemic disease
* Obesity, growth retardation or a clinically diagnosed nutritional disorder
* Previous adenoidectomy or adenotonsillectomy
* Use of systemic corticosteroids, hormone preparations or immunomodulatory drugs within the last 3 months
* Insufficient cooperation during clinical evaluation or sampling, or inability to obtain an adequate blood and/or saliva sample
* Lack of written informed consent from a parent or legal guardian

Control Group

Inclusion Criteria:

* Age 3 to 18 years
* No adenoid or adenotonsillar hypertrophy on clinical and endoscopic evaluation
* No history of nasal obstruction, chronic snoring or sleep-disordered breathing
* Similar age and sex distribution to the patient group
* No known chronic systemic disease and no medical contraindication to venous blood and saliva sampling
* Written informed consent obtained from a parent or legal guardian

Exclusion Criteria:

\* Same exclusion criteria as the patient group

Where it's running

• Harran University Faculty of Medicine Hospital, Department of Otorhinolaryngology
  Sanliurfa, Şanlıurfa, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Servet Erdemes, MD — Harran University
• Study coordinator: Mahmut Ağırtmış, MD
• Email: mahmutagirtmis@harran.edu.tr
• Phone: +905012392163

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.