Left Bundle Branch Area Pacing to Preserve Heart Function in Atrial Fibrillation
Official title: Left Bundle Branch Area Pacing Versus Conventional Right Ventricular Pacing as Initial Strategy for Patients With Permanent Atrial Fibrillation and Preserved Left Ventricular Ejection Fraction Requiring Cardiac Pacing: an Open-label, Multicenter, Randomized Clinical Trial. - the BEAT Study -
Run by Poitiers University Hospital · NCT07759700 · Data updated 2026-11-12
In adults with permanent atrial fibrillation and preserved heart pumping, this study tests whether left bundle branch area pacing helps the heart work better than standard right ventricular pacing.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 642 (estimated) |
| Sponsor | Poitiers University Hospital Academic / other |
| Locations | 1 site (Poitiers) |
| Status | Recruiting |
| Started | October 15, 2026 |
| Main results expected | October 14, 2028 |
| Study ends | August 14, 2030 |
| Registry record updated | October 19, 2026 |
| Trial ID | NCT07759700 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–89 with permanent atrial fibrillation, preserved ejection fraction (≥50%), and an indication for permanent ventricular pacing.
✕Probably not a fit
Patients with indications for additional therapies or with conditions excluded by the criteria may see no benefit from LBBA pacing.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter, randomized trial compares a pacing strategy that targets the heart's natural electrical system (left bundle branch area pacing) with conventional right ventricular pacing. It enrolls adults with atrial fibrillation requiring a pacemaker and preserved ejection fraction to see if LBBA pacing reduces death or heart-failure–related hospitalizations, lowers the need for upgrading to biventricular pacing, and preserves heart function and quality of life over two years. The study uses a 1:1 randomization to receive either LBBA pacing or conventional pacing as the initial pacing approach. Participants undergo implantation with a single-chamber pacemaker and are followed to monitor safety and effectiveness outcomes. The investigation is prospective, open-label, and conducted at multiple centers in France, led by Poitiers University Hospital.
Why it matters
Potential benefit: If successful, LBBA pacing could better maintain heart function and reduce heart-failure complications compared with standard pacing.
How similar studies have gone: Prior studies suggest that more physiological pacing approaches may improve outcomes, but this trial tests LBBA pacing against conventional pacing in a large, contemporary population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years and \<90 years * Atrial fibrillation requiring ventricular pacing because of 1. rapid atrial fibrillation requiring atrioventricular node ablation; or 2. slow atrial fibrillation i.e. ≤ 50 bpm on admission ECG). * Left ventricular ejection fraction ≥50%. * Affiliated person or beneficiary of the French social security scheme * Having given their informed consent. Exclusion Criteria: * Indication for an implantable cardioverter defibrillator. * Presence of a mechanical tricuspid valve * Any prior attempt at implantation of an implantable cardioverter defibrillator, cardiac resynchronization therapy or LBBA pacing * Glomerular filtration rate \<40 mL/min/1,73m2 with CKD-EPI formula * Chronic respiratory failure * Serious medical condition with life expectancy of \<2 years * Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: per os, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy) * Persons benefiting from enhanced protection, i.e. minors, persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection, and finally patients in emergency situations
Where it's running
-
CHU Poitiers
Poitiers, France Recruiting
Study contacts
- Study coordinator: Rodrigue GARCIA, MD, PhD
- Email: sec.rythmologie@chu-poitiers.fr
- Phone: +33516604089
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.