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Learning program for a blood test that detects multiple cancers

REFLECTION: Real World Evidence for Learnings in Early Cancer Detection, a Clinical Practice Learning Program for Galleri®

GRAIL, Inc. · NCT05205967

This study is testing how well a new blood test called Galleri® can detect multiple types of cancer in people who choose to get screened.

Quick facts

Study typeObservational
Enrollment17000 (estimated)
Ages22 Years and up
SexAll
SponsorGRAIL, Inc. (industry)
Locations17 sites (Scottsdale, Arizona and 16 other locations)
Trial IDNCT05205967 on ClinicalTrials.gov

What this trial studies

REFLECTION is a multi-center, observational study that aims to enroll around 17,000 individuals who have chosen to undergo screening with the Galleri® test, a blood-based multi-cancer early detection tool. The study will gather data on the real-world application and effectiveness of Galleri® in clinical settings. Participants will provide informed consent and complete questionnaires to help researchers understand their experiences with the test. This study does not involve any exclusion criteria, making it inclusive for a wide range of participants.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals aged 22 and older who have been ordered the Galleri® test by a healthcare provider.

Not a fit: Patients who are under 22 years old or those who have not been ordered the Galleri® test will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance early cancer detection and improve patient outcomes through timely interventions.

How similar studies have performed: Other studies on multi-cancer early detection tests have shown promising results, indicating potential for success in this approach.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

Participants are eligible to be included in the study only if all of the following criteria apply:

* Participant has the ability to understand and the willingness to sign a written informed consent form (ICF);
* Participant is at least 22 years old at the time of consent;
* A provider or their designee has ordered the Galleri® test; and
* Participant has the ability to comprehend the participant questionnaires.

Exclusion Criteria:

* There are no exclusions

Where this trial is running

Scottsdale, Arizona and 16 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Early Detection of Cancer, Cancer, Multi-cancer early detection, Cancer screening, Circulating cell-free tumor DNA

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.