Lattice‑tip versus irrigated‑tip catheter for cavotricuspid isthmus ablation
Lattice-tip Versus Irrigated-tip Catheter for Linear Ablation of the Cavotricuspid Isthmus. A Multicenter, Randomized Study. (The LINEAR Study)
This test checks whether a lattice‑tip catheter works better than a standard irrigated‑tip catheter for creating lasting cavotricuspid isthmus block in adults undergoing CTI ablation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 96 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mitera Hospital Academic / other |
| Locations | 1 site (Athens, Attikis) |
| Trial ID | NCT07078760 on ClinicalTrials.gov |
What this trial studies
This is a randomized, controlled comparison of two radiofrequency catheter technologies for linear ablation of the cavotricuspid isthmus with equal allocation between groups. The primary procedural efficacy endpoint is persistence of bidirectional CTI block after a 60‑minute waiting period, documented with high‑resolution activation mapping and adenosine provocative testing to exclude dormant conduction. Procedural efficiency endpoints include number of RF lesions, time to bidirectional block, and fluoroscopy exposure, and procedural safety events will be recorded. The trial planned enrollment was 96 patients to provide 80% power to detect the expected difference between catheter types.
Who should consider this trial
Good fit: Adults aged 18 years or older who are undergoing first‑time cavotricuspid isthmus radiofrequency ablation and have not had prior right atrial ablation.
Not a fit: Patients with prior right atrial ablation or those not undergoing CTI ablation are unlikely to benefit from this comparison.
Why it matters
Potential benefit: If successful, this approach could increase the proportion of patients achieving durable CTI bidirectional block while shortening procedure time and reducing radiation exposure.
How similar studies have performed: Preliminary and pilot data have suggested higher acute bidirectional block rates with lattice‑tip designs, but large randomized evidence is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients above 18 years of age undergoing CTI ablation Exclusion Criteria: * Prior right atrium ablation
Where this trial is running
Athens, Attikis
- Mitera General Hospital — Athens, Attikis, Greece (Recruiting)
Study contacts
- Principal investigator: Stylianos Tzeis, MD, PhD, FEHRA — Mitera Hospital
- Study coordinator: Stylianos Tzeis, MD, PhD, FEHRA
- Email: stzeis@hyeia.gr
- Phone: +302106869777
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.