Laser crossectomy with 1470 nm versus 1940 nm to prevent varicose vein recurrence
Official title: The Influence of Laser Crossectomy With Different Wavelengths on Varicose Vein Progression
Run by Pirogov Russian National Research Medical University · NCT07449728 · Data updated 2026-11-12
This will test whether doing a flush laser crossectomy with either a 1470 nm or 1940 nm laser lowers the chance of varicose vein recurrence and heat-related clots in adults with great saphenous vein reflux.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Pirogov Russian National Research Medical University Academic / other |
| Locations | 1 site (Moscow) |
| Status | Recruiting |
| Started | January 20, 2026 |
| Main results expected | January 20, 2028 |
| Study ends | January 20, 2029 |
| Registry record updated | March 4, 2026 |
| Trial ID | NCT07449728 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with primary varicose veins (CEAP C2–C6), documented great saphenous vein reflux >0.5 seconds, GSV diameter ≤12 mm, and ability to consent and attend follow-up are ideal candidates.
✕Probably not a fit
Patients with reflux outside the GSV, prior deep or superficial vein thrombosis, deep venous reflux, pelvic venous insufficiency, current anticoagulant use, or need for pharmacologic prophylaxis are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with primary great saphenous vein reflux (CEAP C2–C6, GSV diameter ≤12 mm, reflux >0.5 s) will receive one of three endovenous approaches: laser crossectomy with 1470 nm, laser crossectomy with 1940 nm, or standard endovenous laser treatment leaving a stump. The trial compares technical success, recurrence at the sapheno-femoral junction, postoperative pain intensity, and rates of endovenous heat-induced thrombosis using clinical and ultrasound follow-up. Investigators expect similar technical efficacy between the two wavelengths but will look for differences in pain and adverse events. Procedures are performed at a single center with standard exclusion criteria to reduce thrombotic risk and with informed consent.
Why it matters
Potential benefit: If successful, the approach could lower recurrence at the sapheno-femoral junction and reduce postoperative pain or endovenous heat-induced thrombosis after EVLT.
How similar studies have gone: Endovenous laser treatment is an established alternative to open surgery, but direct comparisons of flush laser crossectomy at 1470 nm versus 1940 nm are limited and this specific comparison is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>18 years * Primary VVs of Clinical Etiology Anatomy Pathophysiology (CEAP) clinical class of C2-C6 * Reflux along the GSV trunk lasting \>0.5 sec. * GSV trunk diameter ≤12 mm * Informed consent to participate in the study Exclusion Criteria: * Primary reflux outside the GSV trunk (including combined reflux) * History of deep or superficial vein thrombosis * Deep vein reflux * Non-thrombotic or post-thrombotic venous obstruction * Pelvic venous insufficiency * Use of oral anticoagulants * Indication for pharmacological prophylaxis after EVLT * Inability to use radial fiber of 1.4-1.57 mm at the surgeon's discretion * Refusal to participate in the study
Where it's running
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MedSwiss Private Cinic
Moscow, Russia Recruiting
Study contacts
- Principal investigator: Kirill Lobastov, PhD — Pirogov Russian National Research Medical University
- Study coordinator: Kirill Lobastov, PhD
- Email: lobastov_kv@hotmail.com
- Phone: +79852116331
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.