Laparoscopic drainage plus hormonal therapy for large ovarian endometriomas
Official title: Evaluate the Therapy of Large Ovarian Endometrioma
Run by University Hospital, Lille · NCT04704115 · Data updated 2026-11-12
This study will test whether laparoscopic cyst drainage followed by a GnRH agonist helps women of childbearing age with ovarian endometriomas 6 cm or larger have fewer recurrences and preserve ovarian reserve.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | Women only |
| Enrollment | 62 (estimated) |
| Sponsor | University Hospital, Lille Academic / other |
| Locations | 1 site (Lisle-sur-Tarn) |
| Status | Recruiting |
| Started | January 21, 2021 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | December 23, 2025 |
| Trial ID | NCT04704115 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women of childbearing age with one or bilateral ovarian endometriomas measuring 6 cm or larger on ultrasound or MRI who are eligible for laparoscopy and not pregnant.
✕Probably not a fit
Patients with cysts showing radiographic or intraoperative atypia, those who are pregnant, or those with contraindications to GnRH agonists, laparoscopy, or general anesthesia are unlikely to benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational study enrolling women of childbearing age with ovarian endometriomas measuring 6 cm or more. Participants managed at Lille will undergo simple laparoscopic drainage followed by treatment with a GnRH agonist as practiced at the center. The study will track cyst recurrence and ovarian reserve over time, including measurement of anti-Müllerian hormone (AMH) and imaging follow-up. Data will be collected without randomization to compare outcomes of this conservative approach against expected recurrence and reserve patterns.
Why it matters
Potential benefit: If successful, this approach could reduce the need for cystectomy and help preserve ovarian reserve and fertility in women with large endometriomas.
How similar studies have gone: Complete cystectomy has been well studied and lowers recurrence but often reduces ovarian reserve, whereas laparoscopic drainage combined with postoperative hormonal suppression is less well studied and has limited supporting data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Endometrioma size ≥ 6cm determined by MRI or ultrasonography * Women with isolated endometrioma or other extraovarian endometriosis: peritoneal, infiltrating endometriotic lesions and adenomyosis. * Cyst single or bilateral Exclusion Criteria: * Cyst with radiographic or macroscopic in laparoscopy atypia * Pregnancy * Patient with contraindication to GnRH agonist (Enantone® 3,75 mg et Decapeptyl® 3 mg) * Patient with contraindication to laparoscopy * Patient with contraindication to general anesthesia * Subject refusing to participate in the study
Where it's running
-
Hop Jeanne de Flandre Chu Lille
Lisle-sur-Tarn, France Recruiting
Study contacts
- Principal investigator: Chrytèle RUBOD, MD,PhD — University Hospital, Lille
- Study coordinator: Chrytèle RUBOD, MD,PhD
- Email: chrystele.rubod@chru-lille.fr
- Phone: 0320445962
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Comparing surgical techniques for treating endometriomas
This study is testing which of two surgical methods is better at preserving a woman's ability to have children while treating endometriomas.
-
Surgical options to preserve ovaries when treating endometriomas
This trial will see if different surgical methods for treating endometriomas help women who want to get pregnant have higher pregnancy and birth rates and fewer complications.
-
Ethanol sclerotherapy for treating ovarian endometriomas
This study tests if a treatment using ultrasound-guided ethanol can help women with painful ovarian cysts shrink them and reduce their symptoms.
-
Alcohol sclerotherapy for pelvic pain and quality of life in ovarian endometrioma
This trial will try ultrasound-guided alcohol sclerotherapy to see if it reduces pelvic pain and improves quality of life in women aged 18–45 with ovarian endometriomas compared with expectant management.
-
Understanding how the uterus absorbs fluid during early pregnancy
This study is trying to understand how the uterus absorbs fluid during early pregnancy in women, both with and without endometriosis, to learn more about the process.
-
Treatment options for ovarian endometrioma
This study is testing whether a new method using ethanol can treat ovarian endometriomas as well as or better than standard surgery, while also looking at how it affects women's fertility and symptoms over two years.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.