Ketogenic diet for patients with high-grade gliomas and brain metastases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of a classic ketogenic diet (CKD) on patients diagnosed with high-grade gliomas and brain metastases. The CKD is designed to reduce glucose intake and promote ketosis, potentially extending survival for these patients. Participants will receive a tailored diet plan developed by dieticians to meet their energy needs while achieving ketosis. The primary outcome is to assess the efficacy of this dietary intervention compared to historical controls. The study aims to provide insights into the therapeutic potential of dietary changes in managing aggressive brain tumors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-80
* Karnofsky Performance Score of 50 or more.
* Newly diagnosed, histologically confirmed glioblastoma grade 4, or secondary metastases or progression after surgical resection, radiation and chemotherapy.
* Normal function of liver and kidneys
* Ability to sign informed consent form

Exclusion Criteria:

* Diabetes mellitus
* Life expectancy \>3 months
* Inability to adhere to diet
* Inability to give informed consent form
* Cholecystectomy last 1 year (before the study entry)
* Diagnosis of genetic disorder of fat metabolism

Where it's running

• Arezina Kasti
  Chaïdári, Athens, Greece Recruiting
• Attikon University General Hospital
  Athens, Greece Recruiting

Study contacts

• Study coordinator: Arezina N. Kasti, RD
• Email: kastiare@yahoo.gr
• Phone: +306942917860

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.