Joint health, balance, and quality of life in adults with hemophilia A
Quality of Life in Adults With Hemophilia A: Associations With Joint Health, Pain, Dynamic Balance, and Falls
See how joint damage and postural balance relate to quality of life in adults with severe hemophilia A.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 36 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | Male |
| Sponsor | Yuzuncu Yil University Academic / other |
| Locations | 1 site (Van) |
| Trial ID | NCT07523399 on ClinicalTrials.gov |
What this trial studies
This observational project will measure joint status, postural balance, fall history, and health-related quality of life in adults with severe hemophilia A. Eligible participants (age ≥18) with a Hemophilia Joint Health Score (HJHS) single-joint score ≥3 in the knee or ankle will undergo clinical joint exams, standardized balance tests, and validated QoL questionnaires at Van Yuzuncu Yil University. People who use walking aids or who have neurological/psychiatric disorders, chronic inflammatory disease, regular use of medications that affect balance, or recent major lower-extremity surgery are excluded. The study describes associations among arthropathy severity, balance impairment, and daily functioning rather than testing a medical treatment.
Who should consider this trial
Good fit: Adults (≥18) with severe hemophilia A and at least mild knee or ankle joint damage (HJHS single-joint score ≥3) who do not use walking aids are the ideal candidates.
Not a fit: People who use walking aids, have neurological or psychiatric disorders, chronic inflammatory disease, take medications that affect balance, or recently had major lower-extremity surgery are unlikely to qualify or gain direct benefit from this study.
Why it matters
Potential benefit: Findings could help identify patients at higher risk of falls or poor function so clinicians can target rehabilitation and fall-prevention strategies.
How similar studies have performed: Previous observational studies have linked hemophilic arthropathy to reduced mobility and quality of life, but few have specifically examined postural balance and falls in this population.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of severe hemophilia A * Age ≥18 years * A minimum single-joint score of 3 points for the knee or ankle according to the Hemophilia Joint Health Score (HJHS) Exclusion Criteria: * Use of walking aids (e.g., crutches) * Presence of neurological or psychiatric disorders, chronic inflammatory disease, -Regular use of medications that could affect balance, * History of major lower extremity surgery within the previous six months.
Where this trial is running
Van
- Van Yuzuncu Yil University — Van, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Ayse Merve Tat, Assistant Professor
- Email: aysemervetat@yyu.edu.tr
- Phone: +905052431112
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.