IV lidocaine for pain control in lumbar fusion
Official title: Effect of Intraoperative Intravenous Lidocaine Infusion on Postoperative Opioid Consumption and Recovery After Lumbar Fusion Surgery: A Randomized Controlled Trial
Run by Ankara City Hospital Bilkent · NCT07488832 · Data updated 2026-11-12
This project will test whether giving an intravenous lidocaine infusion during elective lumbar fusion reduces opioid use and speeds early recovery in adults aged 18–65.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 110 (estimated) |
| Sponsor | Ankara City Hospital Bilkent Academic / other |
| Locations | 1 site (Ankara) |
| Status | Recruiting |
| Started | April 1, 2026 |
| Main results expected | January 1, 2027 |
| Study ends | March 1, 2027 |
| Registry record updated | September 25, 2026 |
| Trial ID | NCT07488832 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 18–65 years old with ASA physical status I–II who are scheduled for elective lumbar fusion and can give informed consent and cooperate with postoperative assessments.
✕Probably not a fit
Patients with ASA ≥III, BMI >35, chronic opioid use, pregnancy, severe cardiac/hepatic/renal disease, or known lidocaine allergy are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, randomized, placebo-controlled trial enrolling adults (18–65 years, ASA I–II) scheduled for elective lumbar fusion. Participants are randomly assigned to receive an IV lidocaine bolus followed by continuous infusion during surgery or an equivalent-volume saline placebo. The primary outcome is cumulative postoperative opioid consumption in the first 24 hours; secondary outcomes include intraoperative opioid use, postoperative pain scores, and early recovery measures. The intervention is given only during the surgical period and standard perioperative care otherwise continues.
Why it matters
Potential benefit: If successful, the intervention could reduce postoperative opioid requirements, lower opioid-related side effects, and promote faster early recovery after lumbar fusion.
How similar studies have gone: Previous perioperative studies in other surgical populations have shown that systemic lidocaine can reduce pain and opioid use, but evidence specifically for lumbar fusion is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Scheduled for elective lumbar fusion surgery under general anesthesia * American Society of Anesthesiologists (ASA) physical status I-III * Ability to provide written informed consent Exclusion Criteria: * Refusal to participate in the study * ASA physical status ≥IV * Body mass index \>35 kg/m² * Known allergy or hypersensitivity to lidocaine or study medications * Severe cardiac, hepatic, or renal disease * Pregnancy * Neurological disorders affecting pain assessment * Chronic opioid use * Use of opioids or antiemetic drugs before surgery * Inability to cooperate with postoperative assessments
Where it's running
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Ankara Bilkent City Hospital
Ankara, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Gokhan Erdem, MD, PhD — Department of Anesthesiology and Reanimation, Ankara Bilkent City Hospital, Ankara, Turkey
- Study coordinator: Ankara Bilkent City Hospital
- Email: ankarasehir@saglik.gov.tr
- Phone: +90 312 552 6000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.