Itraconazole pulse therapy vs ketoconazole shampoo for scalp seborrheic dermatitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, open-label trial compares two treatments for moderate to severe scalp seborrheic dermatitis: oral itraconazole given in pulse regimens over six months versus topical 2% ketoconazole shampoo with daily then twice-weekly use. Participants aged 14 to 70 with scalp SD are enrolled and assigned to one of the two treatment arms, with outcomes measured by SSD scores and global impressions from clinicians and patients. The study aims to see differences in treatment effectiveness, relapse frequency, patient satisfaction, and side effects, using standard statistical analysis. Malassezia-related inflammation and risk of hepatotoxicity with itraconazole are considerations guiding safety and interpretation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who are interested in taking part in research are between the ages of 14-17 with people who have scalp SD ranging from moderate to severe.

Exclusion Criteria:

* Patients with heart disease. Pregnant women or lactating women liver disease patients as itraconazole can be hepatotoxic uncontrolled hypertension patient taking multiple drugs like oral antidiabetics, lipid lowering drugs, sedatives patient has history to hypersensitvity to either of drugs.

Where it's running

• CMH Bahawalpur
  Chak Eighty-seven -Twelve Left, Punjab Province, Pakistan Recruiting

Study contacts

• Study coordinator: Bakhtawar Rehman, MBBS, FCPS Dermatology
• Email: bakhtawar.rehman09@gmail.com
• Phone: 03328883135

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.