Italian registry of techniques to grow the liver before surgery
Italian Group of Regenerative and Occlusive Worldwide-used Techniques of Hepatic Hypertrophy - IGROWtoh
This project will see how hospitals across Italy use different techniques to make the liver grow before surgery for adults with liver tumors.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna Academic / other |
| Locations | 1 site (Bologna, Bologna) |
| Trial ID | NCT07445412 on ClinicalTrials.gov |
What this trial studies
This is a national, multicenter observational registry that will collect prospective data on adults undergoing techniques to induce liver hypertrophy before resection, with plans to include a retrospective cohort from the prior 10 years. Patients will receive usual local care and be followed from recruitment through their hospital stay, with vital status and events collected for up to five years after surgery where possible. The registry aims to describe trends in technique use, procedural details, and short- and long-term outcomes across participating Italian centers. Data will be used to compare historical and prospective cohorts and to characterize variation in practice and outcomes.
Who should consider this trial
Good fit: Adults (18 or older) with benign or malignant liver tumors who have a future liver remnant deemed insufficient (approximately <20–40%) and who can give informed consent are appropriate candidates.
Not a fit: Pregnant or breastfeeding people and patients whose future liver remnant is already sufficient or who are not receiving hypertrophy techniques are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the registry could help clinicians identify which liver-growth approaches are associated with better surgical outcomes and safer recovery.
How similar studies have performed: Techniques like portal vein embolization and ALPPS have been reported in prior studies with mixed but informative results, so this registry builds on existing clinical experience rather than testing a novel therapy.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 or older * Obtaining informed consent * Patients with liver neoplasia (benign or malignant) and with a future liver remnant volume deemed insufficient (\<20%-40%) by the local multidisciplinary team Exclusion Criteria: * pregnant or breastfeeding woman
Where this trial is running
Bologna, Bologna
- IRCCS Azienda Ospedaliero-Universitario di Bologna — Bologna, Bologna, Italy (Recruiting)
Study contacts
- Principal investigator: Elio Jovine, MD — IRCCS Policlinico di Sant'Orsola - Malpighi (Bologna, Italy)
- Study coordinator: Elio Jovine, MD
- Email: elio.jovine@aosp.bo.it
- Phone: +39 3356468200
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.