Italian registry of techniques to grow the liver before surgery
Official title: Italian Group of Regenerative and Occlusive Worldwide-used Techniques of Hepatic Hypertrophy - IGROWtoh
Run by IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT07445412 · Data updated 2026-11-12
This project will see how hospitals across Italy use different techniques to make the liver grow before surgery for adults with liver tumors.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna Academic / other |
| Locations | 1 site (Bologna, Bologna) |
| Status | Recruiting |
| Started | October 22, 2024 |
| Main results expected | October 2039 |
| Study ends | April 2040 |
| Registry record updated | March 3, 2026 |
| Trial ID | NCT07445412 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18 or older) with benign or malignant liver tumors who have a future liver remnant deemed insufficient (approximately <20–40%) and who can give informed consent are appropriate candidates.
✕Probably not a fit
Pregnant or breastfeeding people and patients whose future liver remnant is already sufficient or who are not receiving hypertrophy techniques are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a national, multicenter observational registry that will collect prospective data on adults undergoing techniques to induce liver hypertrophy before resection, with plans to include a retrospective cohort from the prior 10 years. Patients will receive usual local care and be followed from recruitment through their hospital stay, with vital status and events collected for up to five years after surgery where possible. The registry aims to describe trends in technique use, procedural details, and short- and long-term outcomes across participating Italian centers. Data will be used to compare historical and prospective cohorts and to characterize variation in practice and outcomes.
Why it matters
Potential benefit: If successful, the registry could help clinicians identify which liver-growth approaches are associated with better surgical outcomes and safer recovery.
How similar studies have gone: Techniques like portal vein embolization and ALPPS have been reported in prior studies with mixed but informative results, so this registry builds on existing clinical experience rather than testing a novel therapy.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 or older * Obtaining informed consent * Patients with liver neoplasia (benign or malignant) and with a future liver remnant volume deemed insufficient (\<20%-40%) by the local multidisciplinary team Exclusion Criteria: * pregnant or breastfeeding woman
Where it's running
-
IRCCS Azienda Ospedaliero-Universitario di Bologna
Bologna, Bologna, Italy Recruiting
Study contacts
- Principal investigator: Elio Jovine, MD — IRCCS Policlinico di Sant'Orsola - Malpighi (Bologna, Italy)
- Study coordinator: Elio Jovine, MD
- Email: elio.jovine@aosp.bo.it
- Phone: +39 3356468200
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.