Italian cooperative hemoadsorption for relieving uremic symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

ICHARUS is a prospective, multicenter, observational registry collecting real-world data on hemodialysis combined with hemoadsorption (HAHD) in adults with end-stage kidney disease on maintenance dialysis. Patients are enrolled when their treating physician prescribes hemoadsorption as part of routine care for persistent moderate-to-severe uremic symptoms. The registry records indications, treatment patterns, changes in symptom scores and patient-reported outcomes, and safety events without altering standard clinical practice. Data will describe how HAHD is used across centers and how symptoms and adverse events evolve over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥18 years) with end-stage kidney disease (CKD stage 5D) on maintenance hemodialysis.
* Stable hemodialysis treatment for at least 3 months prior to enrollment.
* Presence of at least one moderate-to-severe uremic symptom, as identified by the Dialysis Symptom Index at screening.
* Planned treatment with hemodialysis combined with hemoadsorption according to local clinical practice.
* Ability to provide written informed consent.

Exclusion Criteria:

* Acute illness, active infection, or hospitalization within 4 weeks prior to enrollment.
* Planned kidney transplantation within the study follow-up period.
* Life expectancy less than 6 months due to non-renal comorbid conditions.
* Inability to complete patient-reported outcome questionnaires.
* Participation in another interventional clinical study that could interfere with study outcomes.

Where it's running

• S.C.D.U. Nefrologia, Dialisi e Trapianto ARNAS G.Brotzu, Cagliari
  Cagliari, Italy, Italy Recruiting

Study contacts

• Study coordinator: Matteo Floris, MD
• Email: matteo.floris@aob.it
• Phone: *393207718720

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.