Irradiation of the subventricular zone with postoperative radiotherapy for glioblastoma patients

A Prospective Phase I/II Clinical Study of SVZ Irradiation With Postoperative Radiotherapy in Patients With GBM.

This study is testing if giving radiation to a specific brain area after surgery can help people with newly diagnosed glioblastoma live longer and feel better while also looking at any side effects.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 40 (estimated)
• Ages: 18 Years to 70 Years
• Sex: All
• Sponsor: Jiangsu Cancer Institute & Hospital (Academic / other)
• Drugs / interventions: bevacizumab, chemotherapy
• Locations: 1 site (Nanjing, Jiangsu)
• Trial ID: NCT06092255 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the safety and efficacy of irradiating the subventricular zone (SVZ) in patients with newly diagnosed glioblastoma (GBM) following radical surgical treatment. Participants will receive postoperative adjuvant radiotherapy combined with temozolomide chemotherapy, followed by maintenance therapy with temozolomide. The study aims to assess the impact of this treatment approach on disease progression and patient outcomes. Patients will be monitored for adverse reactions and can withdraw from the study if necessary.

Who should consider this trial

Good fit: Ideal candidates are treatment-naïve adults aged 18-70 with newly diagnosed glioblastoma who have undergone maximum surgical resection.

Not a fit: Patients with prior brain irradiation or those whose tumors are not close to the SVZ may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could improve treatment outcomes and survival rates for patients with glioblastoma.

How similar studies have performed: While similar approaches have been explored, this specific method of SVZ irradiation combined with postoperative radiotherapy is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Patients voluntarily join this study, have the ability to understand and are willing to sign the informed consent form.

2. Aged between 18-70 years old (inclusive). 3. Newly diagnosed glioblastoma confirmed by pathology. 4. The patient must have undergone maximum surgical resection and start radiotherapy within 12 weeks after surgery.

5. MRI shows that the patient's SVZ area is involved or the distance between the tumor and the SVZ area is less than or equal to 1cm.

6. No previous brain irradiation. 7. Women of childbearing age have a negative urine test or serum pregnancy test and are contraceptive during the treatment period.

8. The ECOG performance status assessed within 7 days before the study intervention is 0-1 points.

9. Have sufficient organ function, and the subject needs to meet the following laboratory indicators:

1. Absolute neutrophil count (ANC) ≥1.5x109/L without using granulocyte colony-stimulating factor in the past 14 days.
2. Without blood transfusion in the past 14 days, platelets are ≥80×109/L.
3. Without blood transfusion or erythropoietin use in the past 14 days, hemoglobin ≥9g/dL (90g/L) or ≥5.6mmol/L.
4. Total bilirubin ≤1.5×upper limit of normal (ULN); or total bilirubin \>1.5×ULN but direct bilirubin ≤SULN.
5. aspartate aminotransferase (AST), alanine aminotransferase (ALT) ≤2.5×ULN, or subjects with liver metastasis ≤5× ULN.
6. Serum creatinine ≤ 1.5 × ULN and creatinine clearance (calculated using the Cockcroft-Gault formula) ≥ 60 ml/min.
7. Good coagulation function: International normalized ratio (INR) or prothrombin time (PT) ≤ 1.5 times ULN; or the subject is receiving anticoagulant therapy but the prothrombin time (PT) or partial thromboplastin time (PTT) is within the therapeutic range for the anticoagulant's intended use; • Activated partial thromboplastin time (aPTT) ) or partial thromboplastin time (PTT) ≤1.5 times ULN; or the subject is receiving anticoagulant therapy, but the prothrombin time (PT) or activated partial thromboplastin time (PTT) is below the expected use of the anticoagulant Within the therapeutic range;
8. Normal thyroid function, defined as thyroid stimulating hormone (TSH) within the normal range. If the baseline TSH is outside the normal range, subjects can also be enrolled if total T3 (or FT3) and FT4 are within the normal range.
9. myocardial enzyme spectrum is within the normal range (such as a simple experiment that is not clinically significant in the comprehensive judgment of the researcher). Ventricular abnormalities are also allowed to be included); simple laboratory abnormalities are also allowed to be included).

Exclusion Criteria:

1. Have a personal history of malignant tumors within two years.
2. Use anti-vascular drugs such as bevacizumab before progression.
3. Women who are pregnant or breastfeeding, and women of childbearing age who are unwilling or unable to accept birth control methods during the entire study period and up to 12 weeks after the study.
4. Physical examination or clinical experimental findings that the researcher believes may interfere with the results or increase the patient's risk of treatment complications.
5. Unstable systemic accompanying diseases (active infection stage, moderate to severe chronic obstructive pulmonary disease, poorly controlled high blood pressure) Blood pressure disease, unstable angina, congestive heart failure, myocardial infarction within 6 months, severe mental disorder requiring drug control, liver, kidney or other metabolic diseases, neuropsychiatric changes such as Alzheimer's disease).
6. There may be other medical history or disease evidence that may interfere with the trial results, prevent the subject from fully participating in the study, abnormal treatment or laboratory test values, or other conditions that the researcher believes are not suitable for enrollment. The researcher believes that there are other potential risks and are not suitable for participation. this research. allowed to join the group).

Where this trial is running

Nanjing, Jiangsu

• Lining Guo — Nanjing, Jiangsu, China (Recruiting)

Study contacts

• Study coordinator: Lining Guo

Conditions GBM