Investigating vascular complications in children diagnosed with type 1 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows children aged 8-18 years who have been diagnosed with type 1 diabetes (T1D) within the last 14 weeks. Over a period of two years, the study aims to assess changes in arterial stiffness, blood pressure, and biomarkers of vascular damage, as well as body composition and dietary habits. By collecting data on these factors, researchers hope to identify the timing and causes of cardiovascular complications in children with T1D. This study is particularly significant as it addresses a gap in knowledge regarding cardiovascular health in Canadian children with T1D.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. Between the ages of 8-18 years
2. Within 14 weeks of type 1 diabetes diagnosis
3. Ability and willingness to undergo non-invasive arterial stiffness assessment for 1hr and willingness to wear the 24-h automated blood pressure monitoring (ABPM) device.

Exclusion Criteria

Children will be ineligible to participate in the study if they meet any of the following:

1. Other cardiometabolic or endocrine diseases diagnosis (type 2 diabetes; familial disorders of cholesterol metabolism; lupus)
2. Other genetic syndromes (Down Syndrome; Prader-Willi)
3. Eating disorder diagnosis
4. Transgender children taking hormone blockers or exogenous sex steroids
5. Currently treated with medications known to affect metabolism (e.g. glucocorticoids, antipsychotics).

Where it's running

• Endocrine and Diabetes Unit, BC Children's Hospital
  Vancouver, British Columbia, Canada Recruiting

Study contacts

• Principal investigator: Angela Devlin, PhD — UBC Pediatrics/BC Children's Hospital Research Institute
• Study coordinator: Angela Devlin, PhD
• Email: adevlin@bcchr.ubc.ca
• Phone: 6048752000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.