Investigating vascular complications in children diagnosed with type 1 diabetes
Understanding Vascular Complications in Children From Type 1 Diabetes Diagnosis
This study is trying to see how type 1 diabetes affects heart health in children aged 8-18 by looking at things like blood pressure and diet over two years.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 8 Years to 18 Years |
| Sex | All |
| Sponsor | University of British Columbia Academic / other |
| Locations | 1 site (Vancouver, British Columbia) |
| Trial ID | NCT05790785 on ClinicalTrials.gov |
What this trial studies
This observational study follows children aged 8-18 years who have been diagnosed with type 1 diabetes (T1D) within the last 14 weeks. Over a period of two years, the study aims to assess changes in arterial stiffness, blood pressure, and biomarkers of vascular damage, as well as body composition and dietary habits. By collecting data on these factors, researchers hope to identify the timing and causes of cardiovascular complications in children with T1D. This study is particularly significant as it addresses a gap in knowledge regarding cardiovascular health in Canadian children with T1D.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 8-18 years who have been diagnosed with type 1 diabetes within the last 14 weeks.
Not a fit: Patients with other cardiometabolic or endocrine diseases, genetic syndromes, or those currently on medications affecting metabolism may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier identification and intervention for cardiovascular complications in children with type 1 diabetes.
How similar studies have performed: While there is limited data on cardiovascular complications in children with T1D in Canada, other studies have indicated early signs of cardiovascular disease in children with T1D, suggesting this approach is relevant and necessary.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria 1. Between the ages of 8-18 years 2. Within 14 weeks of type 1 diabetes diagnosis 3. Ability and willingness to undergo non-invasive arterial stiffness assessment for 1hr and willingness to wear the 24-h automated blood pressure monitoring (ABPM) device. Exclusion Criteria Children will be ineligible to participate in the study if they meet any of the following: 1. Other cardiometabolic or endocrine diseases diagnosis (type 2 diabetes; familial disorders of cholesterol metabolism; lupus) 2. Other genetic syndromes (Down Syndrome; Prader-Willi) 3. Eating disorder diagnosis 4. Transgender children taking hormone blockers or exogenous sex steroids 5. Currently treated with medications known to affect metabolism (e.g. glucocorticoids, antipsychotics).
Where this trial is running
Vancouver, British Columbia
- Endocrine and Diabetes Unit, BC Children's Hospital — Vancouver, British Columbia, Canada (Recruiting)
Study contacts
- Principal investigator: Angela Devlin, PhD — UBC Pediatrics/BC Children's Hospital Research Institute
- Study coordinator: Angela Devlin, PhD
- Email: adevlin@bcchr.ubc.ca
- Phone: 6048752000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.