Investigating Torque Teno Virus as a marker for kidney transplant immunosuppression
Torque Teno Virus: A Biomarker of Immunosuppression in Kidney Transplantation, an Observational Single Centre Study
This study is testing if measuring Torque Teno Virus levels in the blood can help doctors better manage immunosuppression in kidney transplant patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | Queen Mary University of London Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT05756036 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between Torque Teno Virus (TTV) DNA levels and immunosuppression in kidney transplant recipients. By analyzing blood samples collected during routine clinic visits, the study will assess how TTV levels correlate with immunosuppressive drug concentrations and various clinical outcomes, including graft rejection and infections. The goal is to determine if TTV can serve as a reliable biomarker for managing immunosuppression in renal transplant patients.
Who should consider this trial
Good fit: Ideal candidates for this study are consenting renal transplant recipients who are being monitored for immunosuppression.
Not a fit: Patients who are not renal transplant recipients or those who do not consent to participate will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new biomarker to help optimize immunosuppression in kidney transplant patients, potentially reducing the risk of rejection and infections.
How similar studies have performed: Previous studies have indicated the potential of Torque Teno Virus as a biomarker, but this specific approach in the context of kidney transplantation is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All consenting renal transplant recipients in the study period will be included in the study Exclusion Criteria: * no exclusion criteria.
Where this trial is running
London
- Royal London Hospital — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Ramyangshu Chakraborty, MBBS
- Email: ramyangshu.chakraborty@nhs.net
- Phone: 07760781445
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.