Investigating the role of regulatory B cells in fatty liver disease
Role of Regulatory B Cells in the Pathogenesis of Metabolic Associated Fatty Liver Disease
This study is trying to see how certain immune cells called regulatory B cells affect people with fatty liver disease to better understand how the condition develops.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 174 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Asyut) |
| Trial ID | NCT04720560 on ClinicalTrials.gov |
What this trial studies
This study evaluates the role of regulatory B cells in patients diagnosed with metabolic associated fatty liver disease (MAFLD). It aims to understand the pathogenesis of this condition, which has become a significant public health issue due to its rising prevalence. The study will involve patients over 18 years old who have been diagnosed with fatty liver through clinical examinations, laboratory tests, and imaging techniques. By utilizing flow cytometry, the researchers will analyze the regulatory B cells in these patients to gain insights into the disease's mechanisms.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old diagnosed with fatty liver disease.
Not a fit: Patients under 18 years old, pregnant women, those with malignancies, type I diabetes, or those on specific treatments for fatty liver will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of metabolic associated fatty liver disease.
How similar studies have performed: While the role of regulatory B cells in liver diseases is being explored, this specific approach to studying MAFLD is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients aged \>18 years old and was diagnosed as fatty liver based on clinical examination, laboratory investigations and imaging techniques. Exclusion Criteria: * 1-Patients aged ≤18 years old. 2-Pregnancy. 3-Presence of malignancy. 4-Type I DM. 5-Fatty liver patients on treatment by statin derivatives or other medications. 6- Fatty liver patients undergone bariatric surgeries.
Where this trial is running
Asyut
- Medicine — Asyut, Egypt (Recruiting)
Study contacts
- Study coordinator: Amira Mohamed, PhD
- Email: amiramohmad60@gmail.com
- Phone: 0101276047
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.