Investigating the role of collateral circulation in stroke patients undergoing thrombectomy
Registrated Cohort Study on Thrombectomy for Stroke
This study is trying to see how the blood flow in the brain before treatment affects recovery in stroke patients who are getting a procedure to remove a blood clot.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | First Affiliated Hospital of Fujian Medical University Academic / other |
| Locations | 1 site (Fuzhou) |
| Trial ID | NCT04637074 on ClinicalTrials.gov |
What this trial studies
This observational cohort study aims to explore the relationship between baseline collateral circulation and various outcomes in patients with acute ischemic stroke who are candidates for mechanical thrombectomy. It will assess how the status of collateral circulation affects the likelihood of successful arterial occlusion opening, the degree of reperfusion achieved, the extent of tissue injury, and the level of clinical impairment. Patients will undergo CT perfusion imaging before and after the thrombectomy procedure to gather relevant data for analysis.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 years and older who are experiencing an acute ischemic stroke and are eligible for mechanical thrombectomy within 24 hours of symptom onset.
Not a fit: Patients with contraindications to imaging with contrast agents or those who experience significant delays between imaging and thrombectomy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of collateral circulation's impact on stroke outcomes, potentially leading to improved treatment strategies.
How similar studies have performed: While the specific focus on collateral circulation in this context may be novel, previous studies have indicated the importance of collateral circulation in stroke outcomes, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years. * Mechanical thrombectomy initiated within 24 hours after onset * CT perfusion can be performed before the initiation of thrombectomy and 24h after thrombectomy Exclusion Criteria: * Contraindication to imaging with contrast agents * Delay between imaging and beginning of thrombectomy \> 90 minutes
Where this trial is running
Fuzhou
- Department of Neurology, First Affiliated Hospital of Fujian Medical University — Fuzhou, China (Recruiting)
Study contacts
- Study coordinator: Ying M Fu, MD
- Email: fuying@fjmu.eu.cn
- Phone: +8613920263688
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.