Investigating the role of adiponectin in inflammation after major abdominal surgery
Effects of Perioperative Serum Adiponectin on Postoperative Systemic Inflammatory Response in Patients Undergoing Major Abdominal Surgery
This study is trying to see if the levels of a protein called adiponectin in the blood can help explain why some people with obesity have more inflammation and complications after major abdominal surgery for tumors.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Osijek University Hospital Academic / other |
| Locations | 2 sites (Osijek and 1 other locations) |
| Trial ID | NCT06057207 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between blood levels of adiponectin and the systemic inflammatory response in patients undergoing major elective abdominal surgery for gastrointestinal tumors. It focuses on how obesity, characterized by low adiponectin levels, may exacerbate postoperative complications through an exaggerated inflammatory response. By measuring serum levels of adiponectin and inflammatory markers like IL-6, the study seeks to identify potential correlations that could inform postoperative care. The findings may help in understanding the impact of obesity on surgical outcomes and guide interventions to mitigate risks.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who are scheduled for major elective abdominal surgery due to gastrointestinal tumors.
Not a fit: Patients under 18 years old, those with a BMI under 18.5 kg/m2, or those with acute surgical conditions or infections may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for obese patients undergoing major abdominal surgery, potentially reducing postoperative complications.
How similar studies have performed: While the specific correlation between adiponectin levels and postoperative inflammation in this context may be novel, similar studies have indicated that managing inflammatory responses can improve surgical outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Age \>18 years Patient presenting for major elective abdominal surgery of gastrointestinal system according to tumor. Exclusion Criteria: Age\<18 years BMI\<18.5kg/m2 Acute surgical conditions Established acute systemic/local infection Chronic/actual corticosteroid therapy Active immunomodulation therapy Allergie to used anestehetics/analgetics in study.
Where this trial is running
Osijek and 1 other locations
- Osijek University Hospital — Osijek, Croatia (Recruiting)
- Sonja Škiljić — Osijek, Croatia (Recruiting)
Study contacts
- Study coordinator: Sonja Škiljić, MD
- Email: skiljicsonja@gmail.com
- Phone: 3850981947559
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.