Investigating the Role of A2A Receptor in Patients with High Cholesterol
Characterization of Adenosine A2A Receptor Expression and Fubnction in Hypercholesterolemic Patients
This study is testing how high cholesterol affects certain receptors in the blood cells of patients to see if it helps explain the link between cholesterol and heart disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Assistance Publique Hopitaux De Marseille Academic / other |
| Locations | 1 site (Marseille) |
| Trial ID | NCT05017649 on ClinicalTrials.gov |
What this trial studies
This study aims to explore how hypercholesterolemia affects the expression and function of A2A receptors in peripheral blood mononuclear cells (PBMCs). By analyzing a larger cohort of hypercholesterolemic patients, the researchers hope to uncover the mechanisms linking high cholesterol levels to increased cardiovascular disease risk. The study will involve collecting blood samples to assess the A2A receptor's role in the cardiovascular and immune systems of these patients. Understanding these interactions may lead to improved prevention and treatment strategies for cardiovascular conditions associated with high cholesterol.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18-80 with LDL-cholesterol levels greater than 1.9 g/L, with or without treatment for hypercholesterolemia.
Not a fit: Patients who do not have hypercholesterolemia or are currently on cholesterol-modifying therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better prevention and treatment strategies for cardiovascular diseases in patients with hypercholesterolemia.
How similar studies have performed: While the specific role of A2A receptors in hypercholesterolemic patients is less explored, similar studies investigating receptor functions in cardiovascular conditions have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female subjects aged 18-80 years * For the group of hypercholesterolemic patients : * LDL-cholesterol level \>1.9 g/L with or without treatment to make the diagnosis of hypercholesterolemia (laboratory test less than 12 months old at inclusion) * For the healthy group : ● No cholesterol-modifying therapy. * Subject not having hypercholesterolemia (biological assessment less than 12 months old at inclusion with LDL-cholesterol level \< 1.9 g/L) and not taking cholesterol-lowering treatment. * Subjects who are affiliated or beneficiaries of a social security plan * Subject agreeing to participate in the study and having signed an informed consent Exclusion Criteria: * Protected person, as defined by articles L1121-5, L1121-6 and L1121-8 of the Public Health Code: pregnant or breastfeeding woman, person deprived of liberty by judicial decision, adult person unable to give consent. * Person who does not understand the French language
Where this trial is running
Marseille
- Service Endocrinologie — Marseille, France (Recruiting)
Study contacts
- Study coordinator: René Valero
- Email: rene.valero@ap-hm.fr
- Phone: 0491387577
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.