Investigating the Renin Angiotensin Aldosterone System in Pediatric Sepsis
Early Identification of Sepsis-associated Acute Kidney Injury Using Ultrasonography Measurements and Renin and Angiotensin Levels in Children and Adults.
This study is trying to see how the renin-angiotensin-aldosterone system works in children with sepsis compared to healthy kids and to check if it’s different for those with kidney problems.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 74 (estimated) |
| Ages | 1 Day to 18 Years |
| Sex | All |
| Sponsor | Northwell Health Academic / other |
| Locations | 1 site (New Hyde Park, New York) |
| Trial ID | NCT06295393 on ClinicalTrials.gov |
What this trial studies
This observational cohort study aims to compare the renin-angiotensin-aldosterone system (RAAS) in pediatric patients with sepsis against healthy pediatric subjects, as well as between those with and without acute kidney injury (AKI) due to sepsis. Blood samples will be collected on sequential days from septic patients and a single sample from healthy controls, alongside renal ultrasounds performed during hospitalization. The study is designed to enroll a total of 74 patients, with a focus on identifying differences in renin levels between the groups using enzyme-linked immunosorbent assays (ELISA).
Who should consider this trial
Good fit: Ideal candidates include pediatric patients aged 1 day to 18 years diagnosed with sepsis or healthy children within the same age range.
Not a fit: Patients with pre-existing end-stage renal disease, chronic renal failure, or those on specific heart medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the RAAS in pediatric sepsis, potentially leading to improved management strategies for affected children.
How similar studies have performed: While this approach is observational and builds on existing knowledge of RAAS, similar studies have shown promise in understanding sepsis mechanisms, making this a valuable investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * pediatric patients age 1 days - 18 years old with sepsis or age 1 day - 18 years and healthy. Exclusion Criteria: * -pre-existing end stage renal disease (ESRD), chronic renal failure (CRF), home use of angiotensin converting enzyme inhibitor(ACE) or angiotensin receptor blocker(ARB) medications, pre-existing congestive heart failure (CHF), and unrepaired congenital heart disease
Where this trial is running
New Hyde Park, New York
- Cohen Children's Medical Center — New Hyde Park, New York, United States (Recruiting)
Study contacts
- Study coordinator: Grace Fisler, MD
- Email: gfisler@northwell.edu
- Phone: 203-671-0654
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.