Investigating the Renin Angiotensin Aldosterone System in Pediatric Sepsis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study aims to compare the renin-angiotensin-aldosterone system (RAAS) in pediatric patients with sepsis against healthy pediatric subjects, as well as between those with and without acute kidney injury (AKI) due to sepsis. Blood samples will be collected on sequential days from septic patients and a single sample from healthy controls, alongside renal ultrasounds performed during hospitalization. The study is designed to enroll a total of 74 patients, with a focus on identifying differences in renin levels between the groups using enzyme-linked immunosorbent assays (ELISA).

Why it matters

Who can join: the full rules

Inclusion Criteria:

* pediatric patients age 1 days - 18 years old with sepsis or age 1 day - 18 years and healthy.

Exclusion Criteria:

* -pre-existing end stage renal disease (ESRD), chronic renal failure (CRF), home use of angiotensin converting enzyme inhibitor(ACE) or angiotensin receptor blocker(ARB) medications, pre-existing congestive heart failure (CHF), and unrepaired congenital heart disease

Where it's running

• Cohen Children's Medical Center
  New Hyde Park, New York, United States Recruiting

Study contacts

• Study coordinator: Grace Fisler, MD
• Email: gfisler@northwell.edu
• Phone: 203-671-0654

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.