Investigating the NLRP3 Inflammasome's Role in Weight Loss After Sleeve Gastrectomy for Obese Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the role of the NLRP3 inflammasome in the weight loss outcomes of morbidly obese patients following sleeve gastrectomy. It focuses on understanding the mechanisms behind the varying responses to bariatric surgery, particularly in relation to insulin resistance and cardiovascular health. The study will involve women aged 18 to 45 with a BMI of 40 or higher, or 35 with related comorbidities, who have undergone a thorough evaluation and consented to participate. Data will be collected over a 24-month follow-up period to assess the long-term effects of the surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Being a woman between the ages of 18 and 45;
* Have been well informed about bariatric surgery and perioperative risks and have benefited from a multidisciplinary evaluation by a multidisciplinary team (RCP) ;
* Have a BMI greater than or equal to 40 kg/m2 or greater than or equal to 35 kg/m2 with at least one co-morbidity that can be improved after surgery (cardiovascular disease, sleep apnea and severe respiratory disorders, type 2 diabetes, osteoarticular diseases)
* Have been informed of the research on the samples taken during care;
* Having stated its decision not to object to the research on the samples taken during the treatment;
* To have accepted medical and surgical follow-up for 24 months;
* Patient under the general social security system.

Exclusion Criteria:

* Being a pregnant or nursing woman;
* Being a type 1 diabetic;
* Have inflammatory bowel disease;
* Have severe and unstable eating disorders ;
* Have severe, uncontrolled cognitive, mental or psychological disorders;
* Have a cancerous pathology;
* Be addicted to alcohol and psychoactive substances (both legal and illegal);
* Have a life-threatening illness in the short or medium term;
* Have contraindications related to surgical operations in general such as general anaesthesia;
* Be under legal protection measures (guardianship, curators, safeguarding of justice), and person deprived of liberty.

Where it's running

• CHU de Martinique
  Fort-de-France, Martinique Recruiting

Study contacts

• Principal investigator: Emmanuel RIVKINE — CHU de Martinique
• Study coordinator: Jocelyne CRASPAG, MSc
• Email: jocelyne.craspag@chu-martinique.fr
• Phone: +596596592698

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.