Investigating the lung microbiome's impact on endobronchial valve treatment for emphysema

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore how the lung microbiome affects outcomes and complications in patients with chronic obstructive pulmonary disease (COPD) and emphysema undergoing endobronchial valve (EBV) treatment. Patients will have bronchoalveolar lavage (BAL) performed before the insertion of EBVs, with the collected fluid analyzed for bacterial profiling. The study will track the incidence of infections and the need for valve removal or clean-up over a 24-month follow-up period, while also examining changes in the lung microbiome during these procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* COPD patients with emphysema selected for EBV treatment by multidiciplinary team, independent of this study.
* Written informed consent

Exclusion Criteria:

- Intake of oral antibiotics within 1 month before the procedure. Patients receiving preventive long-term treatment with antibiotics can be included.

Where it's running

• Aarhus University Hospital
  Aarhus, Denmark Recruiting

Study contacts

• Study coordinator: Elisabeth Bendstrup, Professor
• Email: karbends@rm.dk
• Phone: +45 7846 2201

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.