Investigating the Loss of Y Chromosome in Aortic Stenosis
Loss of Y Chromosome in Aortic Stenosis
University of Virginia · NCT06595407
This study is testing if losing the Y chromosome in blood cells is linked to developing aortic stenosis in older men.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 40 Years and up |
| Sex | Male |
| Sponsor | University of Virginia (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Charlottesville, Virginia) |
| Trial ID | NCT06595407 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the relationship between the loss of the Y chromosome in circulating blood cells of males and the development of aortic stenosis, a common heart valve disease. Aortic stenosis primarily affects older adults and can lead to severe complications such as heart failure. The study will involve blood analysis to assess the presence of the Y chromosome and its potential association with the condition. By understanding this relationship, researchers hope to uncover new insights into the mechanisms behind aortic stenosis.
Who should consider this trial
Good fit: Ideal candidates for this study are males diagnosed with aortic stenosis, specifically those with a valve area less than 1.5 cm².
Not a fit: Patients with a bicuspid aortic valve, a history of chest radiation, inflammatory diseases, or active cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and potential new therapeutic targets for aortic stenosis in men.
How similar studies have performed: While the specific approach of examining the loss of the Y chromosome in relation to aortic stenosis is novel, similar studies have explored genetic factors in cardiovascular diseases with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aortic stenosis (valve area \<1.5cm2) Exclusion Criteria: * Bicuspid aortic valve * History of radiation to chest * Inflammatory (autoimmune, rheumatologic) disease associated with aortic stenosis * Active cancer
Where this trial is running
Charlottesville, Virginia
- University of Virginia — Charlottesville, Virginia, United States (RECRUITING)
Study contacts
- Study coordinator: Jonathan R Lindner, MD
- Email: jlindner@virginia.edu
- Phone: 434 2979442
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aortic Stenosis, Aortic stenosis, Y-chromosome, Transforming growth factor-beta, Echocardiography