Investigating the long-term effects of maternal hyperglycemia on children's health
The Effect of in Utero Hyperglycaemia, Maternal Overnutrition and Interaction With Postnatal Lifestyle on Cardiometabolic Risk at Young Adulthood - Extension of HAPO Follow-up Study
This study looks at how high blood sugar levels in pregnant women affect their children's health as they grow into young adults.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 900 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong, Hong Kong, China) |
| Trial ID | NCT05477511 on ClinicalTrials.gov |
What this trial studies
This observational study follows a unique cohort of mother-child pairs from the original HAPO study to explore the impact of maternal hyperglycemia during pregnancy on the cardiometabolic health of children as they transition into young adulthood. The study utilizes data from 1760 Chinese pregnant women who underwent a glucose tolerance test, with results kept undisclosed to clinicians and subjects. By analyzing maternal and neonatal health outcomes, the research aims to uncover the long-term risks associated with varying degrees of maternal hyperglycemia. This is the largest cohort study of its kind in a Chinese population, focusing on the Developmental Origin of Health and Disease (DOHaD) model.
Who should consider this trial
Good fit: Ideal candidates for this study are mother-child pairs who participated in the original HAPO study and are now eligible for follow-up assessments.
Not a fit: Patients who were born preterm, are non-Chinese, or whose mothers' OGTT results were disclosed during pregnancy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into preventing cardiometabolic diseases in children exposed to maternal hyperglycemia.
How similar studies have performed: Other studies have shown success in exploring the effects of maternal health on child outcomes, but this specific approach focusing on a Chinese cohort is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Mother-child pairs who had been assessed in HAPO follow-up study at either 7 years or 11-14 years old Exclusion Criteria: * Children born preterm before 37 weeks of gestation * Non-Chinese * Mothers' OGTT results were unblinded during pregnancy
Where this trial is running
Hong Kong, Hong Kong, China
- Prince of Wales Hospital — Hong Kong, Hong Kong, China, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Chi Chiu Wang — Chinese University of Hong Kong
- Study coordinator: Chi Chiu Wang
- Email: ccwang@cuhk.edu.hk
- Phone: +852 35052804
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.