Investigating the link between influenza and invasive pulmonary aspergillosis
Unraveling the Pathogenesis of Influenza-associated Aspergillosis: a Single-center, Prospective Cohort Pilot Study
This study looks at how having the flu affects patients with severe pneumonia in the ICU and whether it leads to more serious lung infections.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 45 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven) |
| Trial ID | NCT03748069 on ClinicalTrials.gov |
What this trial studies
This observational trial aims to explore the immunological and pathological characteristics of patients with severe community-acquired pneumonia in the ICU, comparing those with influenza to those without. The study will include all consecutive patients aged 18 or older who are admitted to the ICU with respiratory distress and a microbiologically confirmed diagnosis of either influenza or non-influenza pneumonia. The findings will be correlated with the occurrence of secondary invasive pulmonary aspergillosis infections, providing insights into the impact of influenza on pneumonia outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older admitted to the ICU with respiratory distress due to microbiologically confirmed influenza or community-acquired pneumonia.
Not a fit: Patients under 18 years old, pregnant women, or those unable to provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the relationship between influenza and secondary infections, potentially improving treatment strategies for affected patients.
How similar studies have performed: While this study focuses on a specific correlation, similar investigations into the effects of viral infections on secondary bacterial or fungal infections have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients older than 18 years, admitted to ICU with respiratory distress with microbiologically confirmed diagnosis of influenza (for inclusion in the influenza group) * All patients older than 18 years, admitted to ICU for respiratory distress due to community- acquired pneumonia , with a microbiologically confirmed absence of influenza (for inclusion in the control group) Exclusion Criteria: * Age \< 18 years old * Pregnant women * No informed consent
Where this trial is running
Leuven
- Universitaire Ziekenhuizen Leuven — Leuven, Belgium (Recruiting)
Study contacts
- Principal investigator: Joost Wauters, PhD — UZ Leuven
- Study coordinator: Joost Wauters, PhD
- Email: joost.wauters@uzleuven.be
- Phone: 16344275
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.