Investigating the link between chemerin levels and diet quality in colorectal cancer patients
Investıgatıon of The Relatıonshıps Between Serum Chemerın Levels, Dıet Qualıty, Inflammatory and Phytochemıcal Indıces in Adults wıth Colorectal Cancer
This study is trying to see how diet affects inflammation in people with colorectal cancer by looking at their chemerin levels and comparing them to healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 104 (estimated) |
| Ages | 19 Years to 64 Years |
| Sex | All |
| Sponsor | Hacettepe University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 2 sites (Ankara and 1 other locations) |
| Trial ID | NCT06018077 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the relationship between serum chemerin levels in individuals diagnosed with colorectal cancer and various inflammatory response parameters, including C-reactive protein and albumin. It will involve 52 colorectal cancer patients and 52 matched healthy individuals, focusing on dietary habits and their impact on inflammation. Participants will undergo body composition analysis and blood tests after fasting to assess their health metrics and dietary intake. The study seeks to compare these findings with those of healthy individuals to better understand the role of diet in cancer-related inflammation.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18-65 who have been newly diagnosed with colorectal cancer (excluding Stage IV) and are at least three weeks post-surgery.
Not a fit: Patients receiving active radiotherapy or chemotherapy, or those with a history of metastasis or other significant health issues, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how dietary quality influences inflammation and cancer progression, potentially guiding dietary recommendations for colorectal cancer patients.
How similar studies have performed: While the relationship between diet and cancer has been explored, this specific investigation into chemerin levels and dietary inflammatory indices in colorectal cancer is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For patient group * Between the ages of 18-65, * At least 3 weeks after surgery * Individuals newly diagnosed with colorectal cancer by a oncolog (except for Stage IV) For healthy group * Between the ages of 18-65, * Healthy adult individuals without any chronic disease Exclusion Criteria: For patient group * Receiving active radiotherapy or chemotherapy, * Existing history of metastasis, * Having a malignant disease other than the diagnosis of colorectal cancer, - History of metabolic syndrome, cardiovascular disease, hepatic disease, chronic kidney disease, major hormonal or hematological disease, pulmonary disease, * With a history of autoimmune disease, with a history of inflammatory diseases (pancreatitis, chron's, ulcerative colitis, etc.), * Those who use nonsteroidal anti-inflammatory drugs (NSAIDs), * Alcoholic and other drug addicts, * Smokers, * Those with mental disorders (major depressive disorder, dementia), * Those who take corticosteroid or hormone therapy, * Those who have an existing infectious disease, those who receive medical nutrition therapy for any disease For healthy group * Individuals aged 18 and under and 65 years and older, * History of metabolic syndrome, cardiovascular disease, hepatic disease, chronic kidney disease, major hormonal or hematological disease, pulmonary disease, * With a history of autoimmune disease, with a history of inflammatory diseases (pancreatitis, chron's, ulcerative colitis, etc.), * Those who use nonsteroidal anti-inflammatory drugs (NSAIDs), * Pregnant and lactating women, * Alcoholic and other drug addicts, * Smokers, those with mental disorders (major depressive disorder, dementia), * Those taking corticosteroid or hormone therapy, * Those with existing infectious disease, * Those receiving medical nutrition therapy for any illness
Where this trial is running
Ankara and 1 other locations
- Hacettepe University Health Science Faculty, Nutrition and Dietetic Department — Ankara, Turkey (Recruiting)
- Ankara Bilkent City Hospital, Oncology Hospital, Medical Oncology Outpatient Clinic — Ankara, Turkey (Recruiting)
Study contacts
- Principal investigator: Semra Bakir Angay — Hacettepe University
- Study coordinator: Semra Bakir Angay
- Email: semrabakir@hacettepe.edu.tr
- Phone: +903123051094
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.