Investigating the impact of environmental pollutants on female fertility
FERTilité féminine, Agents ENvironnementaux et Stress OXydant
This study is trying to see how certain environmental pollutants affect the fertility of women undergoing in vitro fertilization (IVF).
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years to 43 Years |
| Sex | Female |
| Sponsor | University Hospital, Tours Academic / other |
| Locations | 1 site (Tours) |
| Trial ID | NCT04866329 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the effects of various environmental agents, such as bisphenols, ethynylestradiol, and glyphosate, on female fertility. Women undergoing in vitro fertilization (IVF) at the University Hospital of Tours will be recruited to provide blood, urine, and follicular fluid samples, alongside completing a lifestyle questionnaire. The study will assess the relationship between the levels of these pollutants in the samples and the quality of oocytes, as well as the success rates of IVF and pregnancy outcomes. The research seeks to understand how oxidative stress and endocrine disruptors may influence reproductive health.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 18 to 43 who are undergoing their first oocyte retrieval as part of an IVF protocol.
Not a fit: Patients who have previously undergone IVF procedures or are using egg donation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how environmental pollutants affect female fertility, potentially leading to improved IVF outcomes.
How similar studies have performed: While studies have explored the effects of environmental pollutants on fertility, this specific approach focusing on IVF patients and oxidative stress is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Woman aged 18 to 43 years old * First oocyte puncture (IVF rank = 1) Exclusion Criteria: * Opposition to data processing * IVF rank equal or greater than 2 * Egg donation * Intracytoplasmic Sperm Injection with testicular biopsy * Intracytoplasmic Sperm Injection with self-preservation straw * Sperm donation
Where this trial is running
Tours
- Department of Reproductive Medicine and Biology, Univesity Hospital, Tours — Tours, France (Recruiting)
Study contacts
- Principal investigator: Fabrice GUERIF, MD-PhD — University Hospital, Tours
- Study coordinator: Fabrice GUERIF, MD-PhD
- Email: fabrice.guerif@univ-tours.fr
- Phone: 02.47.47.84.76
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.