Investigating the human claustrum's role in epilepsy
Investigating the Role and Electrophysiological Characteristics of the Human Claustrum Based on SEEG
This study is trying to understand how a part of the brain called the claustrum works in people aged 14 to 65 who have epilepsy that doesn’t respond to medication.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Ages | 14 Years to 65 Years |
| Sex | All |
| Sponsor | Xuanwu Hospital, Beijing Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT06575413 on ClinicalTrials.gov |
What this trial studies
This prospective study aims to explore the electrophysiological characteristics and functions of the human claustrum in patients with drug-resistant epilepsy. Utilizing stereoelectroencephalography (SEEG), the study records electrical activity from deep brain structures through implanted electrodes. The focus is on analyzing data from patients aged 14 to 65 who have undergone SEEG implantation, particularly targeting the claustrum. The research seeks to enhance understanding of the connectivity and functional areas of the brain related to epilepsy.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 14 to 65 diagnosed with drug-resistant epilepsy who are undergoing SEEG implantation.
Not a fit: Patients who do not have drug-resistant epilepsy or those who experience surgical complications during the implant procedure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients with refractory epilepsy.
How similar studies have performed: While the approach of investigating the claustrum is relatively novel, similar studies using SEEG have shown promise in understanding brain functions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. The patients were diagnosed with drug-resistant epilepsy. 2. The patients underwent stereoelectroencephalography (SEEG) implantation for pre-surgical evaluation of epilepsy, with at least one electrode target reaching the claustrum 3. Participants/parents/legal guardian provide informed consent for inclusion Exclusion Criteria: 1. Subjects that experience surgical complications during the implant procedure will be excluded from the study
Where this trial is running
Beijing, Beijing
- Xuanwu Hospital,Capital Medical University — Beijing, Beijing, China (Recruiting)
Study contacts
- Principal investigator: Liankun Ren — Xuanwu Hospital, Beijing
- Study coordinator: Liankun Ren, MD
- Email: renlk2022@outlook.com
- Phone: +86 13681576621
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.