Investigating the effects of remimazolam on postoperative delirium in elderly patients
Effect of General Anesthesia With Remimazolam Versus Propofol on Postoperative Delirium in Elderly Patients
This study is testing if a new anesthesia drug called remimazolam can help prevent confusion after surgery in older patients compared to traditional anesthetics.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 190 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Air Force Military Medical University, China Academic / other |
| Locations | 1 site (Xi'an, Shaanxi) |
| Trial ID | NCT06180876 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the impact of remimazolam, a novel ultra-short-acting benzodiazepine, on the incidence of postoperative delirium in elderly patients undergoing elective surgery with general anesthesia. The study compares remimazolam to traditional anesthetics like propofol to determine its safety and efficacy. By focusing on patients aged 65 and older, the trial aims to address the heightened risk of delirium associated with conventional anesthetics. The findings could provide valuable insights into improving anesthesia protocols for vulnerable populations.
Who should consider this trial
Good fit: Ideal candidates for this study are elderly patients aged 65 years and older scheduled for elective surgery requiring general anesthesia.
Not a fit: Patients with significant comorbidities, neurological or psychiatric disorders, or those with a history of substance abuse may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to safer anesthesia practices that reduce the risk of postoperative delirium in elderly patients.
How similar studies have performed: While the use of remimazolam is relatively novel, previous studies on alternative anesthetics have shown promise in reducing postoperative complications, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥65 years * patients scheduled for elective surgery under general anesthesia Exclusion Criteria: * American Society of Anesthesiologists status ≥Ⅳ * history of neurologic or psychiatric diseases * difficulty in communication * abuse of drug or alcohol * suspected allergy to propofol or benzodiazepines
Where this trial is running
Xi'an, Shaanxi
- Xijing hospital, Fourth military medical university — Xi'an, Shaanxi, China (Recruiting)
Study contacts
- Study coordinator: Zhihong Lu
- Email: deerlu23@163.com
- Phone: +8613891975018
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.